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Chemical Structure : Pulrodemstat
CAS No.: 1821307-10-1
Catalog No.: PC-38671Not For Human Use, Lab Use Only.
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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Pulrodemstat (CC90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM.
CC-90011 inhibits gastrin-releasing peptide (GRP) mRNA expression in H209 and H1417 cell lines with IC50 of 3 nM and 4 nM, respectively.
CC-90011 exhibits potent antiproliferative activity (EC50=6 nM, H1417) that correlated with GRP suppression.
CC-90011 exhibits potent on-target induction of cellular differentiation in acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cell lines, and antitumor efficacy in patient-derived xenograft (PDX) SCLC models.
| M.Wt | 451.478 | |
| Formula | C24H23F2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[2-(4-Aminopiperidin-1-yl)-5-(3-fluoro-4-methoxyphenyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl]-2-fluorobenzonitrile |
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1. Kanouni T, et al. J Med Chem. 2020 Dec 10;63(23):14522-14529.
2. Hollebecque A, et al. Clin Cancer Res. 2021 Jan 15;27(2):438-446.
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