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Chemical Structure : JIB-04
CAS No.: 199596-05-9
Catalog No.: PC-72834Not For Human Use, Lab Use Only.
JIB-04 is a pan-Jumonji histone demethylase inhibitor (IC50=230-1100 nM) with epigenetic activity, also potently inhibits SARS-CoV-2 replication in Vero E6 cells with EC50 of 695 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 50 mg | $168 | In stock | |
| 100 mg | Get quote |
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JIB-04 is a pan-Jumonji histone demethylase inhibitor (IC50=230-1100 nM) with epigenetic activity, also potently inhibits SARS-CoV-2 replication in Vero E6 cells with EC50 of 695 nM.
JARID1A (KDM5A) is most sensitive to JIB-04 (IC50=230 nM), shows no inhibition of the mechanistically related TET enzymes.
JIB-04 specifically inhibits the activity of the Jumonji family of histone demethylases in vitro, in cancer cells, and in tumours in vivo.
JIB-04 showed in vitro antiviral activity in multiple cell types, including primary human bronchial epithelial cells, against several DNA and RNA viruses, including porcine coronavirus transmissible gastroenteritis virus.
| M.Wt | 308.769 | |
| Formula | C17H13ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-5-Chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine |
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1. Juhee Son, et al. mBio. 2022 Jan 18;13(1):e0337721.
2. Lei Wang, et al. Nat Commun. 2013;4:2035.
3. J Easmon, et al. J Med Chem. 1997 Dec 19;40(26):4420-5.
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