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GSK-J1

Chemical Structure : GSK-J1

CAS No.: 1373422-53-7

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GSK-J1 (KDM6A/6B inhibitor)

Catalog No.: PC-38508Not For Human Use, Lab Use Only.

GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively.
GSK-J1 also inhibits KDM5B, KDM5C and KDM5A (IC50 = 170, 550 and 6,800 nM respectively), exhibits no activity against a panel of other histone demethylases (IC50 >10 uM).

Physicochemical Properties

M.Wt 389.459
Formula C22H23N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine

References

1. Kruidenier et al. Nature 488 404 PMID: 22842901.

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