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Chemical Structure : GSK-J1
CAS No.: 1373422-53-7
Catalog No.: PC-38508Not For Human Use, Lab Use Only.
GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $88 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | $258 | In stock | |
| 250 mg | Get quote |
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GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively.
GSK-J1 also inhibits KDM5B, KDM5C and KDM5A (IC50 = 170, 550 and 6,800 nM respectively), exhibits no activity against a panel of other histone demethylases (IC50 >10 uM).
| M.Wt | 389.459 | |
| Formula | C22H23N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine |
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1. Kruidenier et al. Nature 488 404 PMID: 22842901.
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