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FTO-43

Chemical Structure : FTO-43

CAS No.: 2640366-38-5

FTO-43 (FTO-43 N)

Catalog No.: PC-49236Not For Human Use, Lab Use Only.

FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM).

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Biological Activity

FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM).
FTO-43 N shows potent antiproliferative effects in glioblastoma, acute myeloid leukemia, and gastric cancer models (SNU-16 cells, IC50=17.7 uM).
FTO-43 N increases m6A and m6Am levels in gastric cancer cells consistent with FTO knockdown, downregulates Wnt/PI3K-Akt signaling in AGS gastric cancer cells.

Physicochemical Properties

M.Wt 346.855
Formula C19H23ClN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(5-(2-Chlorophenyl)furan-2-yl)-N-((3-(pyrrolidin-1-yl)oxetan-3-yl)methyl)methanamine

References

1. Sarah Huff, et al. J Med Chem. 2022 Aug 8. doi: 10.1021/acs.jmedchem.1c02075.

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