Catalog No.: PC-49236Not For Human Use, Lab Use Only.
FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM).
FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM).
FTO-43 N shows potent antiproliferative effects in glioblastoma, acute myeloid leukemia, and gastric cancer models (SNU-16 cells, IC50=17.7 uM).
FTO-43 N increases m6A and m6Am levels in gastric cancer cells consistent with FTO knockdown, downregulates Wnt/PI3K-Akt signaling in AGS gastric cancer cells.
