You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Demethylase-KDM5B inhibitor 27ab
KDM5B inhibitor 27ab

Chemical Structure : KDM5B inhibitor 27ab

CAS No.: 2415224-87-0

KDM5B inhibitor 27ab

Catalog No.: PC-20355Not For Human Use, Lab Use Only.

KDM5B inhibitor 27ab is a potent inhibitor of histone lysine specific demethylase 5B (KDM5B/JARID1B) with IC50 of 24.4 nM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    KDM5B inhibitor 27ab is a potent inhibitor of histone lysine specific demethylase 5B (KDM5B/JARID1B) with IC50 of 24.4 nM.
    KDM5B inhibitor 27ab can bind and stabilize KDM5B and induce the accumulation of H3K4me2/3 in MKN45 cells, bona fide substrates of KDM5B, while keep the amount of H3K4me1, H3K9me2/3 and H3K27me2 without change.
    KDM5B inhibitor 27ab inhibits MKN45 cell proliferation, wound healing and migration in vitro.

    Physicochemical Properties

    M.Wt 434.54
    Formula C25H30N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(4-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide

    References

    1. Bing Zhao, et al. Eur J Med Chem. 2020 Apr 15;192:112161.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: