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Chemical Structure : KDM5B inhibitor 27ab
Catalog No.: PC-20355Not For Human Use, Lab Use Only.
KDM5B inhibitor 27ab is a potent inhibitor of histone lysine specific demethylase 5B (KDM5B/JARID1B) with IC50 of 24.4 nM.
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KDM5B inhibitor 27ab is a potent inhibitor of histone lysine specific demethylase 5B (KDM5B/JARID1B) with IC50 of 24.4 nM.
KDM5B inhibitor 27ab can bind and stabilize KDM5B and induce the accumulation of H3K4me2/3 in MKN45 cells, bona fide substrates of KDM5B, while keep the amount of H3K4me1, H3K9me2/3 and H3K27me2 without change.
KDM5B inhibitor 27ab inhibits MKN45 cell proliferation, wound healing and migration in vitro.
| M.Wt | 434.54 | |
| Formula | C25H30N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bing Zhao, et al. Eur J Med Chem. 2020 Apr 15;192:112161.
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