KDM5B inhibitor 27ab

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Chemical Structure : KDM5B inhibitor 27ab

Catalog No.: PC-20355Not For Human Use, Lab Use Only.

KDM5B inhibitor 27ab is a potent inhibitor of histone lysine specific demethylase 5B (KDM5B/JARID1B) with IC50 of 24.4 nM.

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Biological Activity

KDM5B inhibitor 27ab is a potent inhibitor of histone lysine specific demethylase 5B (KDM5B/JARID1B) with IC50 of 24.4 nM.
KDM5B inhibitor 27ab can bind and stabilize KDM5B and induce the accumulation of H3K4me2/3 in MKN45 cells, bona fide substrates of KDM5B, while keep the amount of H3K4me1, H3K9me2/3 and H3K27me2 without change.
KDM5B inhibitor 27ab inhibits MKN45 cell proliferation, wound healing and migration in vitro.

Physicochemical Properties

M.Wt	434.54
Formula	C25H30N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide

References

1. Bing Zhao, et al. Eur J Med Chem. 2020 Apr 15;192:112161.

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