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Chemical Structure : GSK-J4
CAS No.: 1373423-53-0
Catalog No.: PC-21211Not For Human Use, Lab Use Only.
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively, GSK-J4 s a cell permeable prodrug of GSK-J1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $488 | In stock | |
| 1 g | Get quote |
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GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively, GSK-J4 s a cell permeable prodrug of GSK-J1.
GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with IC50 of 9 uM.
GSK-J4 prevents the JMJD3-induced loss of nuclear H3K27me3 immunostaining in Flag-JMJD3-transfected HeLa cells.
GSK-J4 inhibits JMJD3 expression that is induced by TGF-β1, inhibits H3K4 demethylation at Xist, Nodal, and HoxC13 in female embryonic stem cells.
GSK-J4 attenuates the development of kidney disease in diabetic mice.
| M.Wt | 453.97 | |
| Formula | C24H28ClN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate hydrochloride |
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1. Kruidenier L, et al. Nature. 2012 Aug 16;488(7411):404-8.
2. Majumder S, et al. J Clin Invest. 2018 Jan 2;128(1):483-499.
3. Donas C, et al. J Autoimmun. 2016 Dec;75:105-117.
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