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Chemical Structure : JMJD5 inhibitor 19j
Catalog No.: PC-21085Not For Human Use, Lab Use Only.
JMJD5 inhibitor 19j is a potent selective small molecule inhibitor of 2OG-dependent oxygenase JMJD5 (KDM8), shows high selectivity over other human 2OG oxygenases.
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JMJD5 inhibitor 19j is a potent selective small molecule inhibitor of 2OG-dependent oxygenase JMJD5 (KDM8), shows high selectivity over other human 2OG oxygenases.
JMJD5 inhibitor 19j does not significantly affect U2OS bone osteosarcoma or PC3 prostate adenocarcinoma cells (IC50=10 uM), substantially reduces the growth of A549 lung adenocarcinoma cells with IC50 of 2.1 uM.
JMJD5 inhibitor 19j (1 uM, 24h) significantly induced both micronuclei and 53BP1 bodies in A549 cells.
JMJD5 inhibitor 19j (1 uM, 24h)caused a reduction in G1-phase cells, with a corresponding increase in S- and G2/M-phase cells in A549 cells.
| M.Wt | 340.38 | |
| Formula | C19H20N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lennart Brewitz, et al. J Med Chem. 2023 Aug 10;66(15):10849-10865.
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