| Cat. No. |
Product Name |
Information |
| PC-27104 |
MS3-123
PRMT1 inhibitor
|
MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1. |
| PC-26787 |
TNG456
PRMT5 inhibitor
|
TNG456 is a potent, highly selective, brain-penetrant MTA-cooperative PRMT5 inhibitor with Ki,app of <2 pM, exhibits viability growth inhibition with GI50 of 20 nM for HAP1 MTAP-null cells, 50-fold selective over HAP1 MTAP WT cells. |
| PC-26384 |
METTL9i
METTL9 inhibitor
|
METTL9i is a first-in-class, highly potent, selective and cell-active methyltransferase METTL9 inhibitor with IC50 of 67 nM. |
| PC-26021 |
YL-5092
YTHDC1 inhibitor
|
YL-5092 is a highly potent and selective, first-in-class inhibitor of RNA m6A reader YTHDC1 with IC50 of 7.4 nM and SPR Kd of 29.6 nM. |
| PC-25924 |
DC2-C1
YTHDC2 inhibitor
|
DC2-C1 is a potent and cell-active inhibitor of RNA N6-methyladenosine recognition protein YTHDC2 with IC50 of 168 nM in FP assays, high selectivity over other YTH-domain proteins. |
| PC-25914 |
FLAV-27
G9a inhibitor
|
FLAV-27 is a potent, selective, SAM-competitive, brain-penetrant inhibitor of histone methyltransferase G9a with IC50 of 0.6 nM, with excellent selectivity over GLP (3.2% inhibition at 1 uM). |
| PC-25825 |
I3IN-002
IGF2BP3 inhibitor
|
I3IN-002 is a small molecule inhibitor of RNA-binding protein IGF2BP3, inhibits IGF2BP3-RNA interactions and shows leukemic cell growth-inhibitory activity with IC50 of ~2 µM in wild-type SEM-cells. |
| PC-25505 |
KCC-07
MBD2 inhibitor
|
KCC-07 is a potent, selective and BBB-penetrable inhibitor of MBD2 (methyl CpG binding domain protein 2), prevents binding of MBD2 to methylated DNA, reactivates ADGRB1 expression and prevents MDM2-mediated p53 polyubiquitination. |
| PC-25345 |
SKLB-Y13
YTHDF1 inhibitor
|
SKLB-Y13 is the first, selective small-molecule inhibitor targeting of the YTHDF1 m6A-binding pocket with IC50 of 0.76 uM, has selectivity for YTHDF1 over YTH family proteins. |
| PC-25321 |
IACS-17596
NSD2 inhibitor
|
IACS-17596 is a highly potent, selective and SAM-competitive inhibitor of NSD2 (MMSET, WHSC1) with IC50 of 8.8 nM, >300-fold selective over a KMT panel including NSD1, NSD3 and SETD2. |
| PC-25006 |
SHR2554
EZH2 inhibitor
|
Zeprumetostat (SHR2554) is a potent, highly selective EZH2 inhibitor, specifically inhibits both wild-type (IC50=0.87 nM) and mutant (EZH2(Y641F), IC50=2.68 nM) EZH2 methyltransferase activity with similar potencies. |
| PC-24714 |
PRMT5 inhibitor 16-19F
PRMT5-MTA inhibitor
|
PRMT5 inhibitor 16-19F is a specific synthetic inhibitor of the PRMT5-MTA complex with SPR KD of 2.54, 0.36 and 0.15 uM against apo-PRMT5:MEP50 and SAM- and MTA-bound PRMT5:MEP50 complexes respectively, selectively inhibits MTAP-deleted cancer cell growth. |
