You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)

Request The Product List ofHistone Methyltransferase (HMTase) Histone Methyltransferase (HMTase)

Cat. No. Product Name Information
PC-72468

AH237

PRMT4/5 inhibitor

AH237 (AH-237) is a potent and selective inhibitor for PRMT4 and PRMT5 with IC50 of 2.8 and 0.42 nM, respectively.
PC-72444

JNJ-64619178

PRMT5 inhibitor

JNJ-64619178 (Onametostat, JNJ 64619178) is a selective, and potent PRMT5 inhibitor with Kiapp of 0.77 nM, inhibits the PRMT5/MEP50 complex impairing cancer cell proliferation.
PC-72438

KO-539

menin-MLL inhibitor

KO-539 (Ziftomenib, KO 539) is a potent and selective menin-MLL inhibitor under clinical investigation for treatment of acute myeloid leukemia (AML).
PC-72396

SGC3027N

PRMT7 inhibitor

SGC3027N (SGC-3027N) is a negative control compound for SGC3027, shows markedly less potent (14 uM) against PRMT7 and other protein methyltransferases.
PC-72395

SGC8158

PRMT7 inhibitor

SGC8158 (SGC-8158) is a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM, the active component of it's cell permeable prodrug SGC3027.
PC-72394

SGC3027

PRMT7 inhibitor

SGC3027 (SGC-3027) is the cell permeable prodrug of SGC8158, a potent, selective, and SAM-competitive inhibitor of PRMT7 with IC50 of <2.5 nM.
PC-72393

MRTX1719

PRMT5 inhibitor

MRTX1719 (MRTX-1719) is a potent, selective binder to the PRMT5-MTA complex, selectively inhibits PRMT5 activity in MTAP-deleted cells (HCT116 MTAP-deleted IC50=12 nM) compared to MTAP-wild-type cells.
PC-72366

TDI-11904

EZH2 inhibitor

TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay.
PC-72365

TDI-6118

EZH2 inhibitor

TDI-6118 is a potent, selective brain-penetrant EZH2 inhibitor with IC50 of 14 nM, inhibits cellular H3K27me with IC50 of 580 nM.
PC-72317

EPZ-719

SETD2 inhibitor

EPZ-719 (EPZ 719) is a potent, selective SETD2 histone methyltransferase inhibitor with IC50 of 8 nM.
PC-72299

NSD1 inhibitor BT5

NSD1 inhibitor

NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase with IC50 of 1.4 uM, shows no covalent binding to NSD2.
PC-72295

SW2_152F

CBX2 inhibitor

SW2_152F (SW2 152F, SW2-152F) is a potent, selective, cell permeable CBX2 chromodomain probe, binds to the N-terminal chromodomain (ChD) with Kd of 80 nM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com