| Cat. No. |
Product Name |
Information |
| PC-27974 |
LC-YD17
YTHDC1 inhibitor
|
LC-YD17 is a potent, selective YTH domain-containing protein 1 (YTHDC1) inhibitor with IC50 of 107.12 nM, exhibits growth inhibitory activity in MOLM-13 and THP-1 cells with IC50 of 11.74 and 16.36 uM respectively. |
| PC-27973 |
LC-YD03
YTHDC1 inhibitor
|
LC-YD03 is a potent, selective YTH domain-containing protein 1 (YTHDC1) inhibitor with IC50 of 41.98 nM and BLI Kd of 102 nM, shows little to no activity against YTHDF1, YTHDF2, YTHDF3, and YTHDC2. |
| PC-27909 |
AL398
NSUN6 inhibitor
|
AL398 is a specific small molecule inhibitor of m5C methyltransferase NSUN6 with IC50 of 2.796 uM, shows negligible effects on the stability of other methyltransferases, including NOP2, NSUN2, and METTL3. |
| PC-27906 |
AN465
EV71 inhibitor, METTL3 inhibitor
|
AN465 (AN-465/42162872) is a potent inhibitor of Enterovirus 71 (EV71) with EC50 of 18.48 uM, effectively inhibits m6A methyltransferase METTL3 with IC50 of 1.782 uM and KD of 8.75 uM. |
| PC-27851 |
S-023-0996
EZH2/EGFR inhibitor
|
S-023-0996 is a potent, tumor cell selective, dual inhibitor of EZH2 and EGFR with IC50 of 2.41 nM and 42.18 nM respectively, inhibits tumor cell proliferation, migration and invasion in vitro with superior efficacy and safety than individual drug combinations. |
| PC-27770 |
FCD-11
SET1A/COMPASS inhibitor
|
FCD-11 is a first-in-class, selective small molecule inhibitor of histone methyltransferases COMPASS (Complex of proteins associated with Set1), specifically inhibits the H3K4me3 activity of SET1A/COMPASS and MLL1/COMPASS with IC50 of 1.32 uM and 3.26 uM. |
| PC-27763 |
METTL21A-IN-1
METTL21A inhibitor
|
METTL21A-IN-1 (Compound 6d) is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A, highly selective against a panel of 44 human MTases. |
| PC-27762 |
HK262
METTL21A inhibitor
|
HK262 is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A with IC50 of 1.1 uM. |
| PC-27203 |
TCIP3
p300/CBP-BCL-6 degrader
|
TCIP3 is a cell-permeable lysine acetyltransferase TCIP (KAT-TCIP) and bivalent molecular glue degrader that binds dually to p300/CBP and BCL6, redirects p300/CBP to BCL6, exhibits potent anti-proliferative effect in DLBCL cells. |
| PC-27104 |
MS3-123
PRMT1 inhibitor
|
MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1. |
| PC-26787 |
TNG456
PRMT5 inhibitor
|
TNG456 is a potent, highly selective, brain-penetrant MTA-cooperative PRMT5 inhibitor with Ki,app of <2 pM, exhibits viability growth inhibition with GI50 of 20 nM for HAP1 MTAP-null cells, 50-fold selective over HAP1 MTAP WT cells. |
| PC-26591 |
NSUN2 inhibitor AK
NSUN2 inhibitor
|
NSUN2 inhibitor AK (AK-968/36977265) is a small molecule inhibitor of RNA methyltransferase NSUN2, decreases m5C occupancy and GATM mRNA levels, shows anti-fibrotic efficacy. |
