Cat. No. |
Product Name |
Information |
PC-49729 |
BRD9539
G9a inhibitor
|
BRD9539 is a small molecule inhibitor of histone hethyltransferase of G9a (euchromatin histone methyltransferase 2, EHMT2) with IC50 of 6.3 uM. |
PC-49728 |
UNC0642
G9a/GLP inhibitor
|
UNC0642 (UNC 0642) is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with IC50 of <2.5 nM. |
PC-49699 |
SKLB-03220
EZH2 inhibitor
|
SKLB-03220 (SKLB03220) is a potent, selective EZH2 covalent inhibitor with IC50 of 1.72 nM (EZH2 WT). |
PC-49683 |
CDIBA
METTL3-14 inhibitor
|
CDIBA is an allosteric inhibitors of m6A-RNA methyltransferase, METTL3 -14 complex with IC50 of 17.3 uM, also reported as a cytosolic phospholipase A2 (cPLA2) inhibitor. |
PC-49674 |
IHMT-337
EZH2 inhibitor
|
IHMT-337 (IHMT337) is a potent, highly selective and irreversible EZH2 inhibitor, specifically inhibits the methylation at H3K27. |
PC-49612 |
RK-701
G9a/GLP inhibitor
|
RK-701 (RK701) is a potent, highly selective and reversible histone lysine methyltransferases G9a and G9a-like protein (GLP) inhibitor with IC50 of 23-27 nM and 53 nM, respectively. |
PC-49598 |
WDR5 inhibitor 10
WDR5 inhibitor
|
WDR5 inhibitor 10 is a highly potent, selective and orally active inhibitor of WD repeat domain 5 (WDR5) with TR-FRET Ki value of <0.02 nM, shows potent antiproliferative activity with GI50 of 9.7 nM in MV4:11 cells. |
PC-49506 |
WDR5 WIN site inhibitor 16
WDR5 inhibitor
|
WDR5 WIN site inhibitor 16 is a potent, selective inhibitor of WD repeat domain 5 (WDR5) WIN site with TR-FRET Kd of <0.02 nM, exhibits histone methyltransferase inhibition with IC50 of 2.2 nM. |
PC-49325 |
SGC0946
DOT1L inhibitor
|
SGC0946 (SGC-0946) is a potent, selective inhibitor of protein methyltransferase DOT1L with KD value of 0.06 nM and IC50 of 0.3 nM, reduces the level of methylation of H3K79 in MCF10A cells with IC50 of 8.8 nM. |
PC-38602 |
MI-3
menin-MLL inhibitor
|
MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9. |
PC-38521 |
WDR5 inhibitor 41
WDR5 inhibitor
|
WDR5 inhibitor 41 is a potent, selective and orally bioavailable WDR5 WIN-site inhibitor with TR-FRET Ki value of <0.02 nM, inhibits cell proliferation of MV4:11 and MOLM-13 with IC50 of 13 and 27 nM, respectively. |
PC-73099 |
SKI-73
CARM1 inhibitor
|
SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors. |