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A-893

Chemical Structure : A-893

CAS No.: 1868232-32-9

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A-893 (A 893;A893)

Catalog No.: PC-60423Not For Human Use, Lab Use Only.

A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    A-893 (A893) is a potent, selective and cell active lysine methyltransferase SMYD2 inhibitor with IC50 of 2.8 nM.
    A-893 displays high selectivity against a panel of 31 other methyltransferases (<50% inhibition at 1 uM).
    A-893 reduces p53K370me1 without effects on overall p53 levels in A549 p53 cellular assay, has unexpectedly notable improvement in potency (>80-fold) compared with AZ-505 .

    Physicochemical Properties

    M.Wt 577.547
    Formula C29H38Cl2N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-N-Cyclohexyl-3-[(3,4-dichlorophenethyl)amino]-N-[2-[[2-hydroxy-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl]amino]ethyl]propanamide

    References

    1. Sweis RF, et al. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.

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