| Cat. No. |
Product Name |
Information |
| PC-62758 |
Chaetocin
SU(VAR)3-9 HMTase inhibitor
|
Chaetocin is a potent, specific, SAM-competitive inhibitor of histone H3K9 methyltransferase (HMT) SU(VAR)3-9 with IC50 of 0.6 uM, no actiivty against H4 Lys20-specific HMT PRSET7 and SET7/9. |
| PC-62736 |
CN-SAH
DOT1L inhibitor
|
CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α.. |
| PC-62527 |
PF-06726304
EZH2 inhibitor
|
PF-06726304 is a novel potent enhancer of zeste homolog 2 (EZH2) inhibitor with IC50 of <5 nM, Ki of 0.7/3.0 nM (Wt/Y641N). |
| PC-62526 |
EBI-2511
EZH2 inhibitor
|
EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G. |
| PC-62486 |
M-525
Menin-MLL inhibitor
|
M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays. |
| PC-62485 |
MI-2-2
Menin-MLL inhibitor
|
MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM). |
| PC-62484 |
MI-2-2 hydrochloride
menin-MLL inhibitor
|
MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM). |
| PC-62468 |
EZH2-IN-3
EZH2 inhibitor
|
EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively. |
| PC-62409 |
MMSET-IN-1
NSD2 inhibitor
|
MMSET-IN-1 (NSD2 inhibitor 1) is a potent, selective epigenetic oncogene MMSET (aka NSD2 or WHSC1) inhibitor with Ki/IC50 of 1.6/3.3 uM. |
| PC-62408 |
Sinefungin
Methyltransferase inhibitor
|
Sinefungin (A 9145, RP 32232) is a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 uM). |
| PC-62385 |
UNC-2170 maleate
53BP1 inhibitor
|
UNC-2170 maleate is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain. |
| PC-62384 |
UNC-2170
53BP1 inhibitor
|
UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain. |
