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Cat. No. Product Name Information
PC-62736

CN-SAH

DOT1L inhibitor

CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α..
PC-62527

PF-06726304

EZH2 inhibitor

PF-06726304 is a novel potent enhancer of zeste homolog 2 (EZH2) inhibitor with IC50 of <5 nM, Ki of 0.7/3.0 nM (Wt/Y641N).
PC-62526

EBI-2511

EZH2 inhibitor

EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G.
PC-62486

M-525

Menin-MLL inhibitor

M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays.
PC-62485

MI-2-2

Menin-MLL inhibitor

MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
PC-62484

MI-2-2 hydrochloride

menin-MLL inhibitor

MI-2-2 hydrochloride is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM).
PC-62468

EZH2-IN-3

EZH2 inhibitor

EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively.
PC-62409

MMSET-IN-1

NSD2 inhibitor

MMSET-IN-1 (NSD2 inhibitor 1) is a potent, selective epigenetic oncogene MMSET (aka NSD2 or WHSC1) inhibitor with Ki/IC50 of 1.6/3.3 uM.
PC-62408

Sinefungin

Methyltransferase inhibitor

Sinefungin (A 9145, RP 32232) is a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 uM).
PC-62385

UNC-2170 maleate

53BP1 inhibitor

UNC-2170 maleate is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.
PC-62384

UNC-2170

53BP1 inhibitor

UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain.
PC-62310

A-395N

A-395N is the negative control compound of A-395, which is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM..

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