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TC-5115

Chemical Structure : TC-5115

CAS No.: 2458182-10-8

TC-5115 (TC5115)

Catalog No.: PC-72008Not For Human Use, Lab Use Only.

TC-5115 (TC5115 ) is a potent, selective inhibitor of MLL1 SET domain with IC50 of 15 nM, 48 times more potent than the pan-methyltransferase inhibitor SAH.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TC-5115 (TC5115 ) is a potent, selective inhibitor of MLL1 SET domain with IC50 of 15 nM, 48 times more potent than the pan-methyltransferase inhibitor SAH.

    Physicochemical Properties

    M.Wt 532.62
    Formula C23H32N8O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-2-amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)((1-(thiophen-2-ylmethyl)azetidin-3-yl)methyl)amino)butanoic acid

    References

    1. Chern TR, et al. ACS Med Chem Lett. 2020 May 14;11(6):1348-1352.

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