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DC541

Chemical Structure : DC541

CAS No.: 2606862-00-2

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DC541 (DC 541)

Catalog No.: PC-38209Not For Human Use, Lab Use Only.

DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM.
    DC541 exhibits over 300-fold selectivity to several methyltransferases.
    DC541 inhibited funtions the cellular α-N-terminal methylation level of regulator of chromosome condensation 1 (RCC1, IC50 value of 30 μM) in human colorectal cancer HT29 cells.

    Physicochemical Properties

    M.Wt 529.641
    Formula C30H35N5O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-((S)-6-amino-1-((2-carbamoylphenyl)amino)-1-oxohexan-2-yl)-1-(2-(naphthalen-1-yl)acetyl)pyrrolidine-2-carboxamide

    References

    1. Dongxing Chen, et al. ACS Med Chem Lett. 2021 Mar 1;12(3):485-493.

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