| Cat. No. |
Product Name |
Information |
| PC-23098 |
Igermetostat
EZH2 inhibitor
|
Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2. |
| PC-23080 |
DCPT1061
Type I PRMTs inhibitor
|
DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. |
| PC-23079 |
MS167
PRMT6 inhibitor
|
MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM. |
| PC-23078 |
MS117
PRMT6 inhibitor
|
MS117 is a potent, selective and cell-active covalent PRMT6 inhibitor with Ki of 16 nM and IC50 of 18 nM. |
| PC-23070 |
ZYZ384
SMYD3 inhibitor
|
ZYZ384 is a small molecule inhibitor of histone lysine methyltransferase SMYD3 with KD value of 78 uM, reduces cell proliferation against human hepatoma HepG2 cells with IC50 of 5.23 uM. |
| PC-22999 |
DOT1L R231Q inhibitor 37
DOT1L R231Q inhibitor
|
DOT1L R231Q inhibitor 37 is a first-in-class DOT1L R231Q inhibitor, inhibits proliferation of H460 cells expressing DOT1LR231Q with IC50 of 6.18 uM. |
| PC-22924 |
EML425
CBP/p300 inhibitor
|
EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively. |
| PC-22923 |
MS3745
G9a-like protein inhibitor
|
MS3745 is a potent and selective inhibitor of protein lysine methyltransferase G9a-like protein (GLP) with IC50 of 4 nM, 65-fold selective over G9a. |
| PC-22922 |
MS3748
G9a-like protein inhibitor
|
MS3748 is a potent and selective inhibitor of protein lysine methyltransferase G9a-like protein (GLP) with IC50 of 5 nM, 59-fold selective over G9a. |
| PC-22921 |
EML741
G9a/GLP inhibitor
|
EML741 is a potent, selective inhibitor of H3K9-specific methyltransferases G9a/G9a-like protein (G9a/GLP) with IC50 of 23 nM (G9a), KD of 1.13 uM in MST assays. |
| PC-22846 |
CDYL inhibitor Compound D03
CDYL inhibitor
|
Compound D03 is a potent and selective small-molecule inhibitor of histone methyllysine reader protein chromodomain Y-like (CDYL) with SPR KD of 0.5 uM, disrupts the recruitment of CDYL onto chromatin. |
| PC-22809 |
AM-9747
PRMT5 inhibitor
|
AM-9747 (AM9747) is a potent, selective and MTA cooperative PRMT5 inhibitor, inhibits symmetrical dimethyl arginine methylation (SDMA) levels in HCT116 MTAP-deleted cells with IC50 of 2 nM. |
