| Cat. No. |
Product Name |
Information |
| PC-24016 |
EP652
METTL3 inhibitor
|
EP652 is a potent, selective and in vivo active inhibitor of RNA methyltransferase METTL3 with IC50 of 2 nM (METTL3/14) in SPA primary assays. |
| PC-23957 |
DDD1870799
RNMT inhibitor
|
DDD1870799 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 2.5 uM. |
| PC-23956 |
DDD1060606
RNMT inhibitor
|
DDD1060606 is a small molecule inhibitor o fHsRNMT (RNA guanine-7 methyltransferase)-RAM (RNA guanine-N7 methyltransferase activating subunit) complex, binds competitively with cap and binds effectively to HsRNMT-RAM in the presence of the co-product SAM wth Kd of 1.6 uM. |
| PC-23905 |
CSV0C018875
G9a inhibitor
|
CSV0C018875 is a cell active quinoline based G9a inhibitor with IC50 of 67.02 uM. |
| PC-23904 |
HKMTI-1-248
G9a/GLP inhibitor
|
HKMTI-1-248 is a potent and selective G9a/GLP inhibitor with IC50 of 13 nM (G9a), equipotent against G9a and GLP (G9a-like protein, EHMT1). |
| PC-23903 |
EPZ035544
G9a/GLP inhibitor
|
EPZ035544 is a potent inhibitor of histone methyltransferase G9a/GLP with IC50 of 10 nM/<100 nM respectively. |
| PC-23902 |
ZZM-1220
G9a/GLP inhibitor
|
ZZM-1220 is a potent, selective G9a/GLP covalent inhibitor with IC50 of 458/924 nM respectively. |
| PC-23669 |
ND-L11B
NSD2 degrader
|
ND-L11B is an effective degrader of RE-IIBP and NSD2-long, effectively induces NSD2 degradation with DC50 of 1.48 and 0.80 uM in KMS11 MM cell line, reduces H3K36me2 level in cancer cells. |
| PC-23666 |
Rabdosiin
METTL8 inhibitor
|
Rabdosiin is a tetramer of caffeic acid isolated from the stem of Ocimum sanctum, shows anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase, also is a potential METTL8 inhibitor. |
| PC-23621 |
AS-254
ASH1L inhibitor
|
AS-254 is a highly potent and selective histone lysine methyltransferase ASH1L (absent, small, or homeotic-like 1) inhibitor with IC50 of 94 nM in FP assays, binds to the catalytic SET domain of ASH1L with ITC Kd of 179 nM. |
| PC-23618 |
AS-254s
ASH1L inhibitor
|
AS-254s is a highly potent and selective histone lysine methyltransferase ASH1L (absent, small, or homeotic-like 1) inhibitor with IC50 of 94 nM in FP assays, binds to the catalytic SET domain of ASH1L with ITC Kd of 179 nM. |
| PC-23492 |
ASH1L inhibitor AS-99 TFA
ASH1L inhibitor
|
ASH1L inhibitor AS-99 TFA (AS99) is a first-in-class, potent, selective inhibitor of ASH1L histone methyltransferase with IC50 of 0.79 uM. |
