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Cat. No. Product Name Information
PC-38300

MS1943

EZH2 degrader

MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM.
PC-38218

BAY-155

menin-MLL inhibitor

BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503.
PC-38209

DC541

NTMT1 inhibitor

DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM.
PC-38151

SHIN1

SHMT1/2 inhibitor

SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM.
PC-38150

SHIN2

SHMT1/2 inhibitor

SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1.
PC-38010

MU1656

DOT1L inhibitor

MU1656 (MU 1656 ) is a potent, highly selective inhibitor of histone methyltransferase DOT1L with IC50 of 2 nM.
PC-36119

WDR5 WIN site inhibitor C6

WDR5 inhibitor

WDR5 inhibitor C6 is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
PC-36041

NPD13668

EZH2 inhibitor

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.
PC-35850

LEM-14-1189

NSD2 inhibitor

LEM-14-1189 is a LEM-14 derivative that differentially inhibits the NSDs with in vitro IC50 of 418 μM (NSD1), IC50 of 111 μM (NSD2) and IC50 of 60 μM (NSD3).
PC-35849

LEM-14

NSD2 inhibitor

LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.
PC-35846

VinSpinIn

Spin1 inhibitor

VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family, displays >300-fold selectivity over a panel of methyltransferases.
PC-35810

EPZ020411 dihydrochloride

PRMT6 inhibitor

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).

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