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Cat. No. Product Name Information
PC-49325

SGC0946

DOT1L inhibitor

SGC0946 (SGC-0946) is a potent, selective inhibitor of protein methyltransferase DOT1L with KD value of 0.06 nM and IC50 of 0.3 nM, reduces the level of methylation of H3K79 in MCF10A cells with IC50 of 8.8 nM.
PC-49209

UNC6934

NSD2-PWWP1 inhibitor

UNC6934 is a potent, selective chemical probe ligand targeting the N-terminal PWWP (PWWP1) domain of NSD2 with Kd value of 91 nM, selectively binds in the aromatic cage of NSD2-PWWP1, thereby disrupting its interaction with H3K36me2 nucleosomes.
PC-49020

TC-E 5003

PRMT1 inhibitor

TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9.
PC-47080

MS8511

G9a/GLP inhibitor

MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642.
PC-38602

MI-3

menin-MLL inhibitor

MI-3 is a potent inhibitor of the interaction between menin-MLL with IC50 of 648 nM, binds to menin (Kd = 201 nM) and inhibits the menin-MLL-AF9 interaction in HEK293 cells without affecting protein levels of menin or MLL-AF9.
PC-38535

SGC2085 hydrochloride

CARM1 inhibitor

SGC-2085 hydrochloride is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM).
PC-38521

WDR5 inhibitor 41

WDR5 inhibitor

WDR5 inhibitor 41 is a potent, selective and orally bioavailable WDR5 WIN-site inhibitor with TR-FRET Ki value of <0.02 nM, inhibits cell proliferation of MV4:11 and MOLM-13 with IC50 of 13 and 27 nM, respectively.
PC-73451

Tulmimetostat

EZH2 inhibitor

Tulmimetostat (CPI-0209) is a potent, selective, orally available EZH2 inhibitor with Ki of 140 fM by kinetic analyses and Ki 180 fM by thermal shift assays.
PC-73322

EZM0414

SETD2 inhibitor

EZM 0414 is a potent, selective and orally bioavailable inhibitor of histone methyltransferase SETD2 with biochemical IC50 of 18 nM, >10,000-fold selectivity over other HMTases.
PC-73122

MRK-740

PRDM9 inhibitor

MRK-740 (MRK740) is a first-in-class, potent, selective and cell-active PRDM9 inhibitor with IC50 of 80 nM.
PC-73099

SKI-73

CARM1 inhibitor

SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.
PC-73067

BR-001

PRC2 EED inhibitor

BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM).

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