UZH1a

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Chemical Structure : UZH1a

Catalog No.: PC-20135Not For Human Use, Lab Use Only.

UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b.
UZH1a demonstrated high selectivity towards other protein methyltransferases (as well as several promiscuous protein kinases) at 10 uM.
UZH1a inhibited cellular m6A levels in mRNA fraction in the leukemia cell line MOLM‐13.

Physicochemical Properties

M.Wt	558.73
Formula	C32H42N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)-2-hydroxybenzamide

References

1. Moroz-Omori EV, et al. ChemMedChem. 2021 Oct 6;16(19):3035-3043.

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UZH1a

Biological Activity

Physicochemical Properties

References

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