| Cat. No. |
Product Name |
Information |
| PC-21938 |
Tazemetostat
EZH2 inhibitor
|
Tazemetostat (EPZ-6438) is a potent, selective, SMA-competitive and orally available EZH2 inhibitor with IC50 of 11 and 16 nM in peptide assay and nucleosome assay, respectively. |
| PC-21930 |
CPI-360
EZH2 inhibitor
|
CPI-360 is a potent, selective EZH2 inhibitor with IC50 of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively. |
| PC-21832 |
WDR5 WBM site inhibitor 7k
WDR5 WBM site inhibitor
|
WDR5 WBM site inhibitor 7k is a selective small molecule inhibitor of WDR5 WBM binding site with Ki of 107 nM, inhibits lncRNA-WDR5 complex formation. |
| PC-21619 |
EPZ004777
DOT1L inhibitor
|
EPZ004777 is a potent, selective inhibitor of DOT1L with Ki of 0.3 nM and IC50 of 0.4 nM, selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. |
| PC-21618 |
Pinometostat
DOT1L inhibitor
|
Pinometostat (EPZ-5676) is a potent and selective inhibitor of DOT1L histone methyltransferase activity with Ki of 0.08 nM, 37000-fold selectivity over other methyltransferases. |
| PC-21568 |
BN104
menin-MLL inhibitor
|
BN104 (BNM-1192) is a potent, highly selective small molecule menin-MLL inhibitor, BNM-1192 is very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant (MV-4-11 (AF4 fusion), IC50=3.5 nM). |
| PC-21491 |
DP308
53BP1 inhibitor
|
DP308 is a novel and effective 53BP1 tandem Tudor domain (TTD) inhibitor, disrupts the binding between 53BP1 and H4K20me2 peptide with IC50 of 1.69 uM. |
| PC-21490 |
UNC7648
53BP1 inhibitor
|
UNC7648 is a small molecule inhibitor of the methyl-lysine reader p53 binding protein 1 (53BP1) tandem Tudor domain (TTD) with TR-FRET IC50 of 8.6 uM. |
| PC-21489 |
UNC9512
53BP1 inhibitor
|
UNC9512 is a selective methyl-lysine reader p53 binding protein 1 (53BP1) antagonist, binds the 53BP1 tandem Tudor domain (TTD) with TR-FRET IC50 of 0.46 uM, and SPR/ITC Kd vfalues of 0.17/0.41 uM respectively. |
| PC-21345 |
iPRMT1
PRMT1 inhibitor
|
iPRMT1 is a potent and selective PRMT1 inhibitor with IC50 of 270 nM, shows good selectivity over other PRMTs. |
| PC-21273 |
C220
PRMT5 inhibitor
|
C220 (PRMT5 inhibitor C220) is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 2.4 nM. |
| PC-21272 |
PRT543
PRMT5 inhibitor
|
PRT543 is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 10.8 nM. |
