| Cat. No. |
Product Name |
Information |
| PC-60001 |
PF-06821497 S enantiomer
|
PF-06821497 S enantiomer is a novel potent, selective, orally bioavailable EZH2 inhibitor with Ki of <0.1 and 1.15 nM aginast both wt and mutant Y641N EZH2, respectively. |
| PC-45679 |
XY1
|
XY1 is the inactive control compound of SGC-707, shows no inhibition on PRMT3. |
| PC-45465 |
UNC1079
|
UNC1079 is the piperidine analog of UNC1021, structurally similar but significantly less potent inhibitor for use as a negative control in cellular studies (L3MBTL3 of >10 uM by AlphaScreen, >1000-fold weaker than UNC1215). |
| PC-45680 |
SGC-707
PRMT3 inhibitor
|
SGC-707 (SGC707) is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM, Kd=53 nM). |
| PC-45658 |
MS-023
type I PRMTs inhibitor
|
MS-023 is a potent, selective, and cell-active inhibitor of type I PRMTs with IC50s of 30/119/83/4/5 nM for PRMT1/3/4/6/8 respectively. |
| PC-45727 |
MI-538
Menin-MLL inhibitor
|
MI-538 is potent and selective menin-MLL interaction inhibitor (IC50=21 nM). |
| PC-45726 |
MI-463
Menin-MLL inhibitor
|
MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM). |
| PC-42673 |
BIX-01294
G9a inhibitor
|
BIX-01294 is a specific small molecule G9a histone methyltransferase inhibitor with IC50 of 1.7 uM. |
| PC-45576 |
AMI-1
PRMTs inhibitor
|
AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases. |
| PC-45050 |
BRD-4770
HMTase inhibitor
|
A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells. |
| PC-44291 |
UNC0638
G9a/GLP inhibitor
|
UNC0638 (UNC 0638) is a potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively, |
| PC-45120 |
OICR-9429
WDR5-MLL inhibitor
|
OICR-9429 is a potent, selective, small-molecule antagonist of WDR5-MLL interaction that binds to WDR5 with Kd of 93±28 nM. |
