Chemical Structure : CMP-5
CAS No.: 880813-42-3
Catalog No.: PC-62981Not For Human Use, Lab Use Only.
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.
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CMP-5 (PRMT5-IN-5) is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.
CMP-5 (PRMT5-IN-5) displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes.
CMP-5 (PRMT5-IN-5) for inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
M.Wt | 315.42 | |
Formula | C21H21N3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine |
1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43.
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