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CMP-5

Chemical Structure : CMP-5

CAS No.: 880813-42-3

CMP-5 (PRMT5-IN-5)

Catalog No.: PC-62981Not For Human Use, Lab Use Only.

CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CMP-5 (PRMT5-IN-5) is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells.
CMP-5 (PRMT5-IN-5) displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes.
CMP-5 (PRMT5-IN-5) for inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.

Physicochemical Properties

M.Wt 315.42
Formula C21H21N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine

References

1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43.

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