| Cat. No. |
Product Name |
Information |
| PC-63461 |
LLY-283
PRMT5 inhibitor
|
LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM. |
| PC-63250 |
BAY-6035
|
BAY-6035 is a potent, peptide-competitive inhibitor of histone methyltransferase SMYD3, inhibits in vitro methylation of MEKK2 peptide with IC50 of 88 nM, >100-fold selectivity over other HMTases. |
| PC-43301 |
EPZ020411 hydrochloride
PRMT6 inhibitor
|
EPZ020411 hydrochloride is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
| PC-43300 |
EPZ020411
PRMT6 inhibitor
|
EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7). |
| PC-43259 |
GSK503
EZH2 inhibitor
|
GSK503 is a potent, specific EZH2 methyltransferase inhibitor that inhibits the methyltransferase activity of WT and mutant EZH2 with similar potency (Ki app=3-27 nM). |
| PC-43184 |
CARM1-IN-7g
CARM1 inhibitor
|
CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7). |
| PC-43165 |
EPZ015666
PRMT5 inhibitor
|
EPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM, displays broad selectivity against a panel of other histone methyltransferases. |
| PC-63229 |
PJ-68
PRMT5 inhibitor
|
PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8). |
| PC-43110 |
A-366
G9a/GLP inhibitor
|
A-366 is a potent, highly selective inhibitor of histone methyltransferase G9a/GLP with IC50 of 3/38 nM, >1,000-fold selectivity for G9a over 21 other methyltransferases. |
| PC-42984 |
UNC0379 trifluoroacetate
SETD8 inhibitor
|
UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM. |
| PC-42983 |
UNC0379
SETD8 inhibitor
|
UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM. |
| PC-63136 |
MS012
G9a-like protein inhibitor
|
MS012 is a potent and selective inhibitor of G9a-Like Protein (GLP) lysine methyltransferase with IC50 of 7 nM, shows >30-fold selectivity for GLP over G9a and other methyltransferases.. |
