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Chemical Structure : Furamidine dihydrochloride
Catalog No.: PC-35608Not For Human Use, Lab Use Only.
Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM.
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Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM; exhibits selectivity over PRMT5, PRMT6 and CARM1 (>15-fold); binds duplex DNA in the DNA minor groove selectively at AT rich sites [(A/T)4], Furamidine can also intercalate between GC base pairs of duplex DNA, bind CTG-CAG repeat DNA with nanomolar affinity; synergistically suppresses murine lupus nephritis in vivo combined with Irinotecan; effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions.
| M.Wt | 377.269 | |
| Formula | C18H18Cl2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Antony S, et al. Nucleic Acids Res. 2007;35(13):4474-84.
2. Jenquin JR, et al. ACS Chem Biol. 2018 Aug 27. doi: 10.1021/acschembio.8b00646.
3. Keil A, et al. Arthritis Rheumatol. 2015 Jul;67(7):1858-67.
4. Yan L, et al. J Med Chem. 2014 Mar 27;57(6):2611-22.
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