| Cat. No. |
Product Name |
Information |
| PC-27851 |
S-023-0996
EZH2/EGFR inhibitor
|
S-023-0996 is a potent, tumor cell selective, dual inhibitor of EZH2 and EGFR with IC50 of 2.41 nM and 42.18 nM respectively, inhibits tumor cell proliferation, migration and invasion in vitro with superior efficacy and safety than individual drug combinations. |
| PC-27770 |
FCD-11
SET1A/COMPASS inhibitor
|
FCD-11 is a first-in-class, selective small molecule inhibitor of histone methyltransferases COMPASS (Complex of proteins associated with Set1), specifically inhibits the H3K4me3 activity of SET1A/COMPASS and MLL1/COMPASS with IC50 of 1.32 uM and 3.26 uM. |
| PC-27763 |
METTL21A-IN-1
METTL21A inhibitor
|
METTL21A-IN-1 (Compound 6d) is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A, highly selective against a panel of 44 human MTases. |
| PC-27762 |
HK262
METTL21A inhibitor
|
HK262 is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A with IC50 of 1.1 uM. |
| PC-27333 |
I3IN-122
IGF2BP3 inhibitor
|
I3IN-122 (IGF2BP3-IN-1) is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3). |
| PC-27203 |
TCIP3
p300/CBP-BCL-6 degrader
|
TCIP3 is a cell-permeable lysine acetyltransferase TCIP (KAT-TCIP) and bivalent molecular glue degrader that binds dually to p300/CBP and BCL6, redirects p300/CBP to BCL6, exhibits potent anti-proliferative effect in DLBCL cells. |
| PC-27108 |
EZH2 inhibitor C36
EZH2-PRC2 inhibitor
|
EZH2 inhibitor C36 is a potent, selective and allosteric EZH2-PRC2 inhibitor with IC50 of 2.27 nM in AlphaLisa assays, inhibits both the basal and activated forms of the PRC2 complex containing EZH2, but not EZH1, in a SAM-noncompetitive manner. |
| PC-27104 |
MS3-123
PRMT1 inhibitor
|
MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1. |
| PC-26996 |
TNG917
EHMT1/2 inhibitor
|
TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases. |
| PC-26788 |
AZD3470
PRMT5 inhibitor
|
AZD3470 (AZD-3470) is a potent, seleective MTA-cooperative PRMT5 inhibitor, targets MTAP deficient advanced/metastatic cancer cells. |
| PC-26787 |
TNG456
PRMT5 inhibitor
|
TNG456 is a potent, highly selective, brain-penetrant MTA-cooperative PRMT5 inhibitor with Ki,app of <2 pM, exhibits viability growth inhibition with GI50 of 20 nM for HAP1 MTAP-null cells, 50-fold selective over HAP1 MTAP WT cells. |
| PC-26595 |
SCR-6920
PRMT5 inhibitor
|
SCR-6920 is a potent and selective, oral PRMT5 inhibitor with IC50 of 1.48 nM. |
