You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)

Request The Product List ofHistone Methyltransferase (HMTase) Histone Methyltransferase (HMTase)

Cat. No. Product Name Information
PC-21346

MS1262

G9a/GLP inhibitor

MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively.
PC-21301

NSUN2 inhibitor MY-1B

NSUN2 inhibitor

NSUN2 inhibitor MY-1B is specific, covalent inhibitor of RNA methyltransferase NSUN2 (IC50=1.3 uM) that stereoselectively react with the catalytic C271, has IC50 of 2.4 uM in RNA methylation assays.
PC-21078

METTL3 inhibitor 54

METTL3 inhibitor

METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays.
PC-21038

KTX-1001

NSD2 inhibitor

KTX-1001 is a potent, selective histone methyltransferase NSD2 (WHSC1, MMSET) inhibitor targeting the catalytic SET domain.
PC-21012

EML734

PRMT7/9 inhibitor

EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively.
PC-20645

HKMTI-1-005

G9a/GLP/EZH2 inhibitor

HKMTI-1-005 is a potent, substrate-competitive dual inhibitor of EZH2 and the closely related G9a/GLP H3K9 methyltransferases with IC50 of 0.1 uM (EHMT2).
PC-20135

UZH1a

METTL3 inhibitor

UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b.
PC-20124

DC-PRC2in-01

EZH2-EED inhibitor

DC-PRC2in-01 is a small molecule PRC2 inhibitor targeting EZH2-EED interaction with affinity Kd of 4.56 uM, decreases global H3K27me3 levels in cancer cells.
PC-20002

UNC2327

PRMT3 inhibitor

UNC2327 (UNC-2327) is a potent, allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 of 230 nM.
PC-49859

DS-1594a

Menin-MLL1 inhibitor

DS-1594a (Emilumenib) is a highly potent Menin-MLL1 inhibitor with IC50 of 1.4 nM in cell-free AlphaLISA assays, displays selective growth inhibition against AML and ALL cells with MLL1-r or NPM1c.
PC-49813

EM127

SMYD3 inhibitor

EM127 is a potent, site-specific covalent, second-generation inhibitor of SMYD3 methyltransferase.
PC-49729

BRD9539

G9a inhibitor

BRD9539 is a small molecule inhibitor of histone hethyltransferase of G9a (euchromatin histone methyltransferase 2, EHMT2) with IC50 of 6.3 uM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com