| Cat. No. |
Product Name |
Information |
| PC-21950 |
GSK343
EZH2 inhibitor
|
GSK343 is a highly potent, selective, SAM-competitive, and cell-active EZH2 inhibitor with IC50 of 4 nM and Kiapp of 1.2 nM. |
| PC-21938 |
Tazemetostat
EZH2 inhibitor
|
Tazemetostat (EPZ-6438) is a potent, selective, SMA-competitive and orally available EZH2 inhibitor with IC50 of 11 and 16 nM in peptide assay and nucleosome assay, respectively. |
| PC-21857 |
BI-9321 trihydrochloride
NSD3 inhibitor
|
BI-9321 (BI 9321) trihydrochloride is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
| PC-21842 |
GSK3368715 dihydrochloride
Type 1 PRMT inhibitor
|
GSK3368715 (EPZ019997, GSK-3368715) dihydrochloride is a potent, reversible and SAM uncompetitive type I PRMT inhibitor with Kiapp of 1.5 to 81 nM for PRMT1, 3, 4, 6, and 8. |
| PC-21606 |
KMI169
KMT9 inhibitor
|
KMI169 (KMI-169) is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with ITC Kd of 25 nM and enzymatic IC50 of 50 nM. |
| PC-21491 |
DP308
53BP1 inhibitor
|
DP308 is a novel and effective 53BP1 tandem Tudor domain (TTD) inhibitor, disrupts the binding between 53BP1 and H4K20me2 peptide with IC50 of 1.69 uM. |
| PC-21348 |
Salvianolic acid C
YTHDF1 inhibitor
|
Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1. |
| PC-21346 |
MS1262
G9a/GLP inhibitor
|
MS1262 is a highly potent, selective and brain-penetrant inhibitor of G9a/GLP methylase with IC50 of 19/6 nM, respectively. |
| PC-21301 |
NSUN2 inhibitor MY-1B
NSUN2 inhibitor
|
NSUN2 inhibitor MY-1B is specific, covalent inhibitor of RNA methyltransferase NSUN2 (IC50=1.3 uM) that stereoselectively react with the catalytic C271, has IC50 of 2.4 uM in RNA methylation assays. |
| PC-21272 |
PRT543
PRMT5 inhibitor
|
PRT543 is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 10.8 nM. |
| PC-21078 |
METTL3 inhibitor 54
METTL3 inhibitor
|
METTL3 inhibitor 54 is a potent, selective inhibitor of m6A-RNA writer enzyme methyltransferase-like 3 (METTL3) with IC50 of 54 nM for METTL3/METTL14 in HTRF assays. |
| PC-21038 |
KTX-1001
NSD2 inhibitor
|
Gintemetostat (KTX-1001) is a potent, selective histone methyltransferase NSD2 (WHSC1, MMSET) inhibitor targeting the catalytic SET domain. |
