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Cat. No. Product Name Information
PC-47080

MS8511

G9a/GLP inhibitor

MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642.
PC-38535

SGC2085 hydrochloride

CARM1 inhibitor

SGC-2085 hydrochloride is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM).
PC-73451

Tulmimetostat

EZH2 inhibitor

Tulmimetostat (CPI-0209) is a potent, selective, second-generation EZH2 inhibitor for the treatment of cancers.
PC-73322

EZM0414

SETD2

EZM 0414 is a potent, selective and orally bioavailable inhibitor of histone methyltransferase SETD2 with biochemical IC50 of 18 nM, >10,000-fold selectivity over other HMTases.
PC-73122

MRK-740

PRDM9 inhibitor

MRK-740 (MRK740) is a first-in-class, potent, selective and cell-active PRDM9 inhibitor with IC50 of 80 nM.
PC-73067

BR-001

PRC2 EED inhibitor

BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM).
PC-73054

PFI-5

SMYD2 inhibitor

PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM.
PC-72992

SMYD3 inhibitor 29

SMYD3 inhibitor

SMYD3 inhibitor 29 is a highly potent, selective, covalent inhibitor of histone methyltransferase SMYD3 with IC50 of 1.7 nM.
PC-72793

SNDX5613

menin-MLL inhibitor

Revumenib (SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with Ki of 0.149 nM.
PC-72792

VTP50469

menin-MLL inhibitor

VTP50469 (VTP 50469) is potent, selective, orally active inhibitor of Menin-MLL interaction with Ki of 104 pM.
PC-72640

SGC6870N

PRMT6 inhibitor

SGC6870N is the negative control of SGC-6870 (R-isomer), which is a potent, selective, cell-active PRMT6 inhibitor.
PC-72639

SGC6870

PRMT6 inhibitor

SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM.

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