| Cat. No. |
Product Name |
Information |
| PC-49679 |
METTL3 inhibitor UZH2
METTL3 inhibitor
|
METTL3 inhibitor UZH2 is a potent, selective and cell-permeable RNA methyltransferase METTL3 inhibitor with IC50 of 5 nM in TR-FRET assays. |
| PC-49674 |
IHMT-337
EZH2 inhibitor
|
IHMT-337 (IHMT337) is a potent, highly selective and irreversible EZH2 inhibitor, specifically inhibits the methylation at H3K27. |
| PC-49612 |
RK-701
G9a/GLP inhibitor
|
RK-701 (RK701) is a potent, highly selective and reversible histone lysine methyltransferases G9a and G9a-like protein (GLP) inhibitor with IC50 of 23-27 nM and 53 nM, respectively. |
| PC-49559 |
PRT382
PRMT5 inhibitor
|
PRT382 (PRT-382) is a potent, selective and SAM-competitive PRMT5 inhibitor with IC50 of 2.8 nM in filtration binding assays with recombinant human PRMT5/MEP50 and histone H2A as the protein substrate. |
| PC-49558 |
CWI1-2
IGF2BP2 inhibitor
|
CWI1-2 is a small molecule inhibitor of m6A reader IGF2BP2, shows promising anti-leukemia effects in vitro and in vivo. |
| PC-49393 |
EPIC-0412
HOTAIR-EZH2 inhibitor
|
EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis. |
| PC-49325 |
SGC0946
DOT1L inhibitor
|
SGC0946 (SGC-0946) is a potent, selective inhibitor of protein methyltransferase DOT1L with KD value of 0.06 nM and IC50 of 0.3 nM, reduces the level of methylation of H3K79 in MCF10A cells with IC50 of 8.8 nM. |
| PC-49209 |
UNC6934
NSD2-PWWP1 inhibitor
|
UNC6934 is a potent, selective chemical probe ligand targeting the N-terminal PWWP (PWWP1) domain of NSD2 with Kd value of 91 nM, selectively binds in the aromatic cage of NSD2-PWWP1, thereby disrupting its interaction with H3K36me2 nucleosomes. |
| PC-49020 |
TC-E 5003
PRMT1 inhibitor
|
TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9. |
| PC-47080 |
MS8511
G9a/GLP inhibitor
|
MS8511 is a first-in-class G9a/GLP covalent, irreversible inhibitor with IC50 of 100/140 nM respectively, displays improved potency in enzymatic and cellular assays compare with noncovalent G9a/GLP inhibitor UNC0642. |
| PC-38535 |
SGC2085 hydrochloride
CARM1 inhibitor
|
SGC-2085 hydrochloride is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM). |
| PC-73451 |
Tulmimetostat
EZH2 inhibitor
|
Tulmimetostat (CPI-0209) is a potent, selective, orally available EZH2 inhibitor with Ki of 140 fM by kinetic analyses and Ki 180 fM by thermal shift assays. |
