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Chemical Structure : DF-A7
Catalog No.: PC-22438Not For Human Use, Lab Use Only.
DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3.
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DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3.
DF-A7 predictively binds to the YTHDF2 protein at the K416, G463, K521, N518, and R527 sites, forming a total of seven hydrogen bonds.
DF-A7 increases the mRNA expression of Cx3cl1 and PRR5 after degrading YTHDF2.
DF-A7 (12.5 mg/kg) significantly inhibited tumor growth compared with vehicle control in both MC38 and B16-OVA tumor models, significantly prolonged the survival of mice.
DF-A7 inhibits tumor growth and improves antitumor efficacy when in combination with PD-1/PD-L1 blockade therapy.
| M.Wt | 446.50 | |
| Formula | C22H30N4O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xiao S, et al. Sci Immunol. 2024 May 31;9(95):eadl2171.
2. Durand M, et al. J Exp Clin Cancer Res. 2024 May 22;43(1):148.
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