Catalog No.: PC-22438Not For Human Use, Lab Use Only.
DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3.
DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3.
DF-A7 predictively binds to the YTHDF2 protein at the K416, G463, K521, N518, and R527 sites, forming a total of seven hydrogen bonds.
DF-A7 increases the mRNA expression of Cx3cl1 and PRR5 after degrading YTHDF2.
DF-A7 (12.5 mg/kg) significantly inhibited tumor growth compared with vehicle control in both MC38 and B16-OVA tumor models, significantly prolonged the survival of mice.
DF-A7 inhibits tumor growth and improves antitumor efficacy when in combination with PD-1/PD-L1 blockade therapy.
