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AMG193

Chemical Structure : AMG193

CAS No.: 2790567-82-5

AMG193 (AMG-193)

Catalog No.: PC-22135Not For Human Use, Lab Use Only.

AMG193 (AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor, exhibits selective antitumor activity in MTAP-null cancer models.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AMG193 (AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor, exhibits selective antitumor activity in MTAP-null cancer models.

Physicochemical Properties

M.Wt 444.41
Formula C22H19F3N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(4-Amino-1,3-dihydrofuro[3,4-c][1,7]naphthyridin-8-yl)[(3S)-3-[4-(trifluoromethyl)phenyl]-4-morpholinyl]methanone

References

1. Patent WO2022132914A1.

2. Adam Radzimierski, et al. Cancer Res (2024) 84 (6_Supplement): 4598.

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