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Chemical Structure : AMG193
CAS No.: 2790567-82-5
Catalog No.: PC-22135Not For Human Use, Lab Use Only.
AMG193 (AMG-193) is a potent, selective and MTA-cooperative PRMT5 inhibitor with IC50 of 107 nM in MTAP deleted cells, binds to the PRMT5-MTA complex with an extremely high affinity (3.9 pM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $488 | In stock | |
| 10 mg | $728 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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| M.Wt | 444.41 | |
| Formula | C22H19F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4-Amino-1,3-dihydrofuro[3,4-c][1,7]naphthyridin-8-yl)[(3S)-3-[4-(trifluoromethyl)phenyl]-4-morpholinyl]methanone |
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1. Patent WO2022132914A1.
2. Adam Radzimierski, et al. Cancer Res (2024) 84 (6_Supplement): 4598.
3. Belmontes B, et al. Cancer Discov. 2024 Sep 16. doi: 10.1158/2159-8290.CD-24-0887.
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