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Cat. No. Product Name Information
PC-22290

AZ506

SMYD2 inhibitor

AZ506 is a potent, selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 17 nM, inhibits SMYD2 mediated methylation of monomethyl p53 peptide in U2OS cells with IC50 of 1.02 uM.
PC-21951

EPZ005687

EZH2 inhibitor

EPZ005687 is a potent, selective and SAM-competitive inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity over EZH1 and 500-fold selectivity against 15 other protein methyltransferases.
PC-21940

UNC1999

EZH2 inhibitor

UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively.
PC-21939

GSK126

EZH2 inhibitor

GSK126 (GSK2816126A) is a potent, highly selective, and SAM-competitive inhibitor of EZH2 methyltransferase with IC50 of 9.9 nM.
PC-21930

CPI-360

EZH2 inhibitor

CPI-360 is a potent, selective EZH2 inhibitor with IC50 of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively.
PC-21832

WDR5 WBM site inhibitor 7k

WDR5 WBM site inhibitor

WDR5 WBM site inhibitor 7k is a selective small molecule inhibitor of WDR5 WBM binding site with Ki of 107 nM, inhibits lncRNA-WDR5 complex formation.
PC-21345

iPRMT1

PRMT1 inhibitor

iPRMT1 is a potent and selective PRMT1 inhibitor with IC50 of 270 nM, shows good selectivity over other PRMTs.
PC-21273

C220

PRMT5 inhibitor

C220 (PRMT5 inhibitor C220) is a highly potent, selective and SAM cpmpetitive inhibitor of protein arginine methyltransferase 5 (PRMT5) with IC50 of 2.4 nM.
PC-21040

EPZ033294

SMYD2 inhibitor

EPZ033294 is a potent, selective inhibitor of SMYD2 with biochemical IC50 of 3.9 nM, and function of cellular methylation IC50 of 29 nM.
PC-21039

EPZ028862

SMYD3 inhibitor

EPZ028862 is a potent, selective inhibitor of SMYD3 with biochemical IC50 of 1.8 nM, and function of cellular methylation IC50 of 32 nM.
PC-21013

EML1219

PRMT9 inhibitor

EML1219 is a selective small molecule inhibitor of protein arginine methyltransferase isoform PRMT9 with IC50 of 0.2 uM.
PC-20906

EPIC-0307

PRADX-EZH2 inhibitor

EPIC-0307 is a selective small-molecule inhibitor of PRADX-EZH2 interaction, inhibits GBM cell lines with IC50 of 12.13-17.69 uM, enhances temozolomide (TMZ) sensitivity to glioblastoma.

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