| Cat. No. |
Product Name |
Information |
| PC-25565 |
RK-552
NSD2 inhibitor
|
RK-0080552 (RK-552) is a potent, specific small molecule NSD2 inhibitor with IC50 of 0.11 uM, weakly inhibits G9a (IC50=1.2 uM) and does not inhibit SET7/9. |
| PC-25506 |
LH168
WDR5 inhibitor
|
LH168 is a potent, exquisitely selective WDR5 chemical probe inhibitor with EC50 of 10 nM in cellulo target engagement NanoBRET assays, SPR KD of 1.9 nM. |
| PC-25447 |
DNMT2 inhibitor 16
DNMT2 inhibitor
|
DNMT2 inhibitor 16 is a potent, selective DNMT2 (TRDMT1) inhibitor with ITC KD of 3.04 uM, reduces m5C levels in MOLM-13 tRNA and synergizes with doxorubicin to impair cell viability, targeting a cryptic allosteric binding site. |
| PC-25273 |
UNC0646
G9a inhibitor
|
UNC0646 (UNC 0646) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 6 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 26 nM. |
| PC-25272 |
UNC0631
G9a inhibitor
|
UNC0631 (UNC 0631) is a potent, selective and cell-active inhibitor of G9a methyltransferase with IC50 of 4 nM in SAHH-coupled assays, reduces H3K9me2 levels in MDA-MB-231 cells with IC50 of 25 nM. |
| PC-24896 |
KMT9 inhibitor 7b
KMT9 inhibitor
|
KMT9 inhibitor 7b is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
| PC-24895 |
KMT9 inhibitor 8
KMT9 inhibitor
|
KMT9 inhibitor 8 is the ethyl ester prodrug of KMT9 inhibitor 7b, a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with Kd of 10 nM. |
| PC-24527 |
HH2853
EZH1/2 inhibitor
|
HH2853 is a novel potent dual EZH1/2 inhibitor that effectively inhibit the catalytic activity of wild-type EZH2 and mutated forms (A677G, Y641F, Y641N, and Y641C) with IC50 of 3.75, 2.21, 2.65, and 2.62 nM respectively, synchronously suppresses EZH1 activity with IC50 of 9.26 nM. |
| PC-24375 |
CM112
PRMT1 degrader
|
CM112 is a potent, selective PRMT1 degrader designed by tethering adamantane to MS023 via a 5-PEG linker, has DC50 of 0.83 uM in MCF-7 cells. |
| PC-24292 |
Dual CARM1-IKZF3 inhibitor 074
CARM1/IKZF3 inhibitor
|
Dual CARM1-IKZF3 inhibitor 074 is a compound composed of the CARM1 inhibitor EZM2302, linked to pomalidomide, increases CRBN-dependent IKZF1, IKZF3, ZFP91, and FGD3 protein degradation, inhibits CRAM1 with IC50 of 2 nM. |
| PC-24105 |
YTHDF2 Inhibitor CK-75
YTHDF2 inhibitor
|
YTHDF2 Inhibitor CK-75 is a specific small molecule inhibitor of YTHDF2, potentially binds to a small hydrophobic pocket on the YTH domain (KD=26.2 uM), potently inhibits the protein-RNA interaction of YTHDF2. |
| PC-24018 |
STC-15
METTL3 inhibitor
|
STC-15 is a small molecule, orally active inhibitor of RNA methyltransferase METTL3, restrains cancer growth and induces anti-cancer immunity. |
