| Cat. No. |
Product Name |
Information |
| PC-22922 |
MS3748
GLP inhibitor
|
MS3748 is a potent and selective inhibitor of protein lysine methyltransferase G9a-like protein (GLP) with IC50 of 5 nM, 59-fold selective over G9a. |
| PC-22921 |
EML741
G9a/GLP inhibitor
|
EML741 is a potent, selective inhibitor of H3K9-specific methyltransferases G9a/G9a-like protein (G9a/GLP) with IC50 of 23 nM (G9a), KD of 1.13 uM in MST assays. |
| PC-22846 |
CDYL inhibitor Compound D03
CDYL inhibitor
|
Compound D03 is a potent and selective small-molecule inhibitor of histone methyllysine reader protein chromodomain Y-like (CDYL) with SPR KD of 0.5 uM, disrupts the recruitment of CDYL onto chromatin. |
| PC-22809 |
AM-9747
PRMT5 inhibitor
|
AM-9747 (AM9747) is a potent, selective and MTA cooperative PRMT5 inhibitor, inhibits symmetrical dimethyl arginine methylation (SDMA) levels in HCT116 MTAP-deleted cells with IC50 of 2 nM. |
| PC-22768 |
Enzomenib
menin-MLL inhibitor
|
Enzomenib (DSP-5336) is a potent, and orally bioavailable menin-MLL interaction inhibitor with IC50 of 1.4 nM, directly binds to the menin protein with Kd of 6 nM. |
| PC-22701 |
W4032
G9a/NSD2 inhibitor
|
G9a/NSD2 dual inhibitor 16 (W4032) is a highly potent G9a/NSD2 dual inhibitor with IC50 of 241/17 nM respectively, shows potent cell growth inhibition against PANC-1 and MDA-MB-231 with IC50 values of 0.44 and 0.72 μM, respectively. |
| PC-22670 |
Thiol methyltransferase inhibitor DCMB
METTL7A inhibitor
|
Thiol methyltransferase inhibitor DCMB is a small moelcule inhibitor of thiol methyltransferase (TMT) with IC50 of 1.17 uM for METTL7A (TMT1A). |
| PC-22471 |
DC-Y13-27
YTHDF2 inhibitor
|
DC-Y13-27 is a specific inhibitor of N6-methyladenosine (m6A) reader YTHDF2, inhibits YTHDF2 binding to m6A-containing RNA with IC50 of 21.8 uM, directly binds to YTHDF2 with a binding constant (KD) of 37.9 uM in MST assay. |
| PC-22438 |
DF-A7
YTHDF2 inhibitor
|
DF-A7 a specific small-molecule degrader/inhibitor of m6A reader YTHDF2 with IC50 of 50 nM in immunoblotting assays (HEK 293T cells), induces degradation of YTHDF2 without affecting the degradation of YTHDF1 and YTHDF3. |
| PC-22432 |
MS152
EHMT2/G9a inhibitor
|
MS152 is a potent, selective and brain penetrant EHMT2/G9a inhibitor with biochemical IC50 of 126 nM/76 nM, respectively. |
| PC-22428 |
YTHDC1 inhibitor 40
YTHDC1 inhibitor
|
YTHDC1 inhibitor 40 (YTHDC1-IN-1) is a potent, selective m6A reader YTHDC1 inhibitor with ITC Kd of 49 nM, HTRF IC50 of 0.35 uM. |
| PC-22335 |
iCARM1
CARM1 inhibitor
|
iCARM1 (ZINC65534584) is a potent, selective inhibitor of protein arginine methyltransferase CARM1 (PRMT4) with IC50 of 12.3 uM, Biacore Kd of 0.67 uM. |
