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Cat. No. Product Name Information
PC-35849

LEM-14

NSD2 inhibitor

LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.
PC-35846

VinSpinIn

Spin1 inhibitor

VinSpinIn is a potent, cell active chemical probe for the Spin family protein with Kd of 10-130 nM for across the family, displays >300-fold selectivity over a panel of methyltransferases.
PC-35810

EPZ020411 dihydrochloride

PRMT6 inhibitor

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).
PC-44245

AZ505

SMYD2 inhibitor

AZ505 (AZ-505, AZ 505) is a potent and selective inhibitor of protein lysine methyltransferase SMYD2 with IC50 of 0.12 uM, displays >600-fold against other histone methyltransferases, such as SMYD3 and EZH2.
PC-35634

OTS186935

SUV39H2 inhibitor

OTS186935 (OTS-186935) is a potent, in vivo-active inhibitor of protein methyltransferase SUV39H2 with IC50 of 6.49 nM, inhibits A549 cell growth with IC50 of 0.67 uM.
PC-35633

OTS193320

SUV39H2 inhibitor

OTS193320 (OTS-193320) is a potent inhibitor of protein methyltransferase SUV39H2 with IC50 of 22.2 nM.
PC-35608

Furamidine dihydrochloride

Tdp1 inhibitor, PRMT1 inhibitor

Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM.
PC-35591

MAK683

PRC2 EED inhibitor

MAK683 (MAK-683) is a potent and selective EED inhibitor with biochemical IC50 of 9 nM, and allosteric inhibitor of polycomb repressive complex 2 (PRC2), selectively binds to the domain of EED that interacts with H3K27me3).
PC-35520

PF-06855800

PRMT5 inhibitor

PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM.
PC-35432

Gambogenic acid

EZH2 inhibitor

Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge, shows potent antitumor activity and can effectively inhibit the survival and proliferation of cancer cells.
PC-35431

GNA002

EZH2 inhibitor

GNA002 (GNA-002) is a gambogenic acid (GNA) derivative that specifically and covalently binds to Cys668 within the EZH2-SET domain, trigges EZH2 degradation (IC50=1.1 uM) through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination.
PC-35247

WDR5-MLL1 inhibitor

WDR5-MLL1 inhibitor

WDR5-MLL1 inhibitor is a novel potent inhibitor of WDR5-MLL1 interaction, binds to WDR5 with Kd of 1 nM.

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