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SKI-73

Chemical Structure : SKI-73

CAS No.: 2206744-61-6

SKI-73 (CARM1 inhibitor, SKI73)

Catalog No.: PC-73099Not For Human Use, Lab Use Only.

SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.

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    Biological Activity

    SKI-73 is a CARM1 chemical probe with pro-drug properties, can readily penetrate cell membranes and then be processed into two active CARM1 inhibitors.
    SKI-73 (10 uM) fully suppresses the methylation of BAF155 Arg1064 in MCF-7 cells.
    SKI-73 inhibits in vitro invasion but not proliferation of breast cancer cells ( MDA-MB-231 cell, EC50=1.3 uM).
    SKI-73 recapitulates the anti-invasion effect of the genetic perturbation of CARM1.
    Either CARM1 knockout or CARM1 inhibition with SKI-73 alters the epigenetic plasticity in a proliferation-independent manner by replacing the most invasion-prone subpopulation with the non-invasive subpopulation(s) to suppress the invasive phenotype.

    Physicochemical Properties

    M.Wt 851.018
    Formula C46H58N8O8
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2S,5S)-6-((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-((benzylamino)methyl)-N-(4-methoxyphenethyl)-2-(3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamido)hexanamide

    References

    1. Xiao-Chuan Cai, et al. Elife. 2019 Oct 28;8:e47110.

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