PFI-5 | SMYD2 inhibitor | Probechem Biochemicals

Chemical Structure : PFI-5

PFI-5 (SMYD2 inhibitor PFI-5, PFI5)

Catalog No.: PC-73054Not For Human Use, Lab Use Only.

PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM.

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Biological Activity

PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM.
PFI-5 inhibits p53 methylation in MCF7 cells with EC50 of 1.3 uM, with no toxicity.

Physicochemical Properties

M.Wt	501.679
Formula	C29H39N7O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-(3-(4-amino-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl)-3-methylazetidin-1-yl)(1-((1-(cyclohept-2-en-1-yl)piperidin-4-yl)methyl)-1H-pyrrol-3-yl)methanone

References

1. Taylor AP, et al. J Med Chem. 2019 Sep 12;62(17):7669-7683.

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PFI-5 (SMYD2 inhibitor PFI-5, PFI5)

Biological Activity

Physicochemical Properties

References

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