Cat. No. |
Product Name |
Information |
PC-72293 |
BI-9321
NSD3-PWWP1 inhibitor
|
BI-9321 (BI 9321) is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM. |
PC-72291 |
PRC2 EED-IN-1
PRC2 EED inhibitor
|
PRC2 EED-IN-1 is a potent, selective, allosteric, orally bioavailable inhibitor of the EED subunit of histone methyltransferase PRC2 with IC50 of 44 nM (H3K27me3 inhibition). |
PC-72290 |
OR-S0
EZH2 inhibitor
|
OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM). |
PC-72288 |
ZLD1039
EZH2 covalent inhibitor
|
ZLD1039 (ZLD 1039) is a potent, highly selective, and orally bioavailable small molecule inhibitor of EZH2 with IC50 of 5.6, 15, 4.0 nM against EZH2 WT, Y641F, and A677G mutations respectively. |
PC-72287 |
SKLB-03176
EZH2 covalent inhibitor
|
SKLB-03176 (SKLB03176) is a potent, selective, covalent EZH2 inhibitor with IC50 of 47 nM, covalently binds to the SAM pocket of EZH2. |
PC-72046 |
MI-3454
menin-MLL1 inhibitor
|
MI-3454 (MI 3454) is a highly potent, orally bioavailable inhibitor of the menin-MLL1 interaction with IC50 of 0.51 nM, 60-fold improvement over MI-503. |
PC-72008 |
TC-5115
MLL1 SET domain
|
TC-5115 (TC5115 ) is a potent, selective inhibitor of MLL1 SET domain with IC50 of 15 nM, 48 times more potent than the pan-methyltransferase inhibitor SAH. |
PC-36120 |
WDR5 WIN site inhibitor C3
|
WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM. |
PC-35608 |
Furamidine dihydrochloride
|
Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM. |
PC-35247 |
WDR5-MLL1 inhibitor
|
WDR5-MLL1 inhibitor is a novel potent inhibitor of WDR5-MLL1 interaction, binds to WDR5 with Kd of 1 nM.. |
PC-43184 |
CARM1-IN-7g
|
CARM1-IN-7g is a potent, selective coactivator-associated arginine methyltransferase 1 (CARM1) with IC50 of 8.6 uM, exhibits lower or no activity against a panel of different PRMTs or HKMTs (>80-fold over PRMT1 and SET7). |
PC-63022 |
E-72
|
G9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2. |