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Chemical Structure : CM-272
CAS No.: 1846570-31-7
Catalog No.: PC-60255Not For Human Use, Lab Use Only.
CM-272 (CM272) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 8 nM and 382 nM for G9a and DNMT1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CM-272 (CM272) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 8 nM and 382 nM for G9a and DNMT1, respectively.
CM-272 also inhibits DNMT3A/3B/GLP with IC50 of 85/1,200/2 nM, respectively.
CM-272 inhibits cell proliferation and promotes apoptosis in different haematological neoplasias (AML, ALL and DLBCL).
CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.
| M.Wt | 478.637 | |
| Formula | C28H38N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine |
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1. San José-Enériz E, et al. Nat Commun. 2017 May 26;8:15424.
2. Bárcena-Varela M, et al. Hepatology. 2018 Jul 16. doi: 10.1002/hep.30168.
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