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CM-579

Chemical Structure : CM-579

CAS No.: 1846570-40-8

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CM-579 (CM579;CM 579)

Catalog No.: PC-60256Not For Human Use, Lab Use Only.

CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.
CM-579 also inhibits DNMT3A/3B with IC50 of 92/1,000 nM, respectively.
CM-579 inhibits cell proliferation and promotes apoptosis in different haematological neoplasias (AML, ALL and DLBCL).

Physicochemical Properties

M.Wt 492.664
Formula C29H40N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine

References

1. San José-Enériz E, et al. Nat Commun. 2017 May 26;8:15424.

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