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Chemical Structure : CM-579
CAS No.: 1846570-40-8
Catalog No.: PC-60256Not For Human Use, Lab Use Only.
CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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CM-579 (CM579) is a novel potent, selective and reversible dual inhibitor of G9a/DNMTs with IC50 of 16 nM and 32 nM for G9a and DNMT1, respectively.
CM-579 also inhibits DNMT3A/3B with IC50 of 92/1,000 nM, respectively.
CM-579 inhibits cell proliferation and promotes apoptosis in different haematological neoplasias (AML, ALL and DLBCL).
| M.Wt | 492.664 | |
| Formula | C29H40N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine |
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1. San José-Enériz E, et al. Nat Commun. 2017 May 26;8:15424.
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