PF-06821497 S enantiomer
(PF06821497 S enantiomer)
Catalog No.: PC-60001Not For Human Use, Lab Use Only.
PF-06821497 S enantiomer is the S enantiomer of PF-06821497, a potent, selective, orally bioavailable EZH2 inhibitor with Ki of <0.1 and 1.15 nM aginast both wt and mutant Y641N EZH2, respectively.
PF-06821497 S enantiomer is the S enantiomer of PF-06821497, a potent, selective, orally bioavailable EZH2 inhibitor with Ki of <0.1 and 1.15 nM aginast both wt and mutant Y641N EZH2, respectively.
PF-06821497 weakly inhibits EZH1 (Ki=70 nM) and no significant affinity against a panel of other HMTases.
PF-06821497 inhibits Karpas-422 cell proliferation with IC50 of 23 nM, cell H3K27me3 IC50 of 17 nM; shows robust tumor growth inhibition in vivo.
