| Cat. No. |
Product Name |
Information |
| PC-45120 |
OICR-9429
WDR5-MLL inhibitor
|
OICR-9429 is a potent, selective, small-molecule antagonist of WDR5-MLL interaction that binds to WDR5 with Kd of 93±28 nM. |
| PC-45608 |
EPZ031686
SMYD3 inhibitor
|
EPZ031686 (EPZ 031686) is a potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM, Cell IC50= 36 nM). |
| PC-42405 |
GSK3326595
PRMT5 inhibitor
|
Pemrametostat (GSK3326595, EPZ015938) is a potent, selective, reversible and orally active PRMT5 inhibitor with IC50 of 22 nM. |
| PC-42321 |
EED226
PRC2 inhibitor
|
EED226 (EED 226) is a potent, selective, orally bioavailable PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED (IC50=22 nM). |
| PC-45115 |
EPZ-011989 trifluoroacetate
EZH2 inhibitor
|
EPZ-011989 trifluoroacetate is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM. |
| PC-45114 |
EPZ-011989
EZH2 inhibitor
|
EPZ-011989 (EPZ011989) is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM. |
| PC-42113 |
MS049
PRMT4/6 inhibitor
|
MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34±10 nM and 43±7 nM, respectively. |
| PC-42097 |
EPZ-015866
PRMT5 inhibitor
|
EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM. |
| PC-42198 |
SGC2085
CARM1 inhibitor
|
SGC2085 is a potent, selective protein arginine methyltransferase PRMT4 (CARM1) inhibitor with IC50 of 50 nM, displays >100-fold selectivity over other PRMTs (PRMT6 IC50=5.3 uM). |
| PC-42272 |
UNC3866
CBX7 inhibitor
|
UNC3866 is a potent, selective PRC1 chromodomains antagonist that binds to CBX4 and CBX7 with Kd of 100 nM. |
| PC-42740 |
UNC0224
G9a/GLP inhibitor
|
UNC0224 (UNC-0224) is a potent, selective G9a/GLP inhibitor with IC50 of 57 nM and 58 nM in biochemical assays. |
| PC-42081 |
A-196
SUV420H2 inhibitor
|
A-196 is a potent, selective and substrate-competitive inhibitor of protein lysine methyltransferases (PKMTs) SUV420H1 and SUV420H2 with IC50 of 25 nM and 144 nM, respectively. |
