| Cat. No. |
Product Name |
Information |
| PC-45726 |
MI-463
Menin-MLL inhibitor
|
MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM). |
| PC-42673 |
BIX-01294
G9a inhibitor
|
BIX-01294 is a specific small molecule G9a histone methyltransferase inhibitor with IC50 of 1.7 uM. |
| PC-45576 |
AMI-1
PRMTs inhibitor
|
AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases. |
| PC-45050 |
BRD4770
G9a inhibitor
|
BRD4770 is a SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells. |
| PC-44291 |
UNC0638
G9a/GLP inhibitor
|
UNC0638 (UNC 0638) is a potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively, |
| PC-45120 |
OICR-9429
WDR5 inhibitor
|
OICR-9429 is a potent, selective, small-molecule antagonist of WDR5-MLL interaction that binds to WDR5 with Kd of 93±28 nM. |
| PC-45608 |
EPZ031686
SMYD3 inhibitor
|
EPZ031686 (EPZ 031686) is a potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM, Cell IC50= 36 nM). |
| PC-42405 |
GSK3326595
PRMT5 inhibitor
|
Pemrametostat (GSK3326595, EPZ015938) is a potent, selective, reversible and orally active PRMT5 inhibitor with IC50 of 22 nM. |
| PC-42321 |
EED226
PRC2 inhibitor
|
EED226 (EED 226) is a potent, selective, orally bioavailable PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED (IC50=22 nM). |
| PC-45115 |
EPZ-011989 trifluoroacetate
EZH2 inhibitor
|
EPZ-011989 trifluoroacetate is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM. |
| PC-45114 |
EPZ-011989
EZH2 inhibitor
|
EPZ-011989 (EPZ011989) is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM. |
| PC-42113 |
MS049
PRMT4/6 inhibitor
|
MS049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC50 of 34±10 nM and 43±7 nM, respectively. |
