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EML631

Chemical Structure : EML631

CAS No.: 2101206-36-2

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EML631 (EML-631)

Catalog No.: PC-70163Not For Human Use, Lab Use Only.

EML631 (EML 631) is a small-molecule inhibitor of the methyl-lysine reader protein Spindlin1 (SPIN1) with Kd of 4 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EML631 (EML 631) is a small-molecule inhibitor of the methyl-lysine reader protein Spindlin1 (SPIN1) with Kd of 4 uM.
    EML631 shows increased selectivity and engages SPIN1 in cells.
    EML631 block its ability to 'read' H3K4me3 marks and inhibit its transcriptional-coactivator activity.

    Physicochemical Properties

    M.Wt 684.97
    Formula C41H60N6O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2-((4-(pyrrolidin-1-ylmethoxy)phenyl)amino)-1,4-phenylene)bis((4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)methanone)

    References

    1. Bae N, et al. Nat Chem Biol. 2017 May 15. doi: 10.1038/nchembio.2377.

    2. Wang W, et al. EMBO Rep. 2011 Oct 28;12(11):1160-6.

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