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EML633

Chemical Structure : EML633

CAS No.: 2101954-85-0

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EML633 (EML-633)

Catalog No.: PC-70164Not For Human Use, Lab Use Only.

EML633 (EML 633) small-molecule inhibitor of methyllysine reader protein SPIN1 (Spindlin 1) with Kd of 2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    EML633 (EML 633) small-molecule inhibitor of methyllysine reader protein SPIN1 (Spindlin 1) with Kd of 2 uM.
    EML 633 shows increased selectivity and engages SPIN1 in cells, block its ability to 'read' H3K4me3 marks and inhibit its transcriptional-coactivator activity.

    Physicochemical Properties

    M.Wt 682.998
    Formula C42H62N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2-((3-(2-(pyrrolidin-1-yl)ethyl)phenyl)amino)-1,4-phenylene)bis((4-(2-(pyrrolidin-1-yl)ethyl)piperidin-1-yl)methanone)

    References

    1. Bae N, et al. Nat Chem Biol. 2017 May 15. doi: 10.1038/nchembio.2377.

    2. Wang W, et al. EMBO Rep. 2011 Oct 28;12(11):1160-6.

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