BAY-598 (BAY598) is a potent, selective, and cell-active, substrate-competitive inhibitor of SMYD2 with IC50 of 27±7 nM in the biochemical SPA assay.
BAY-598 displays >100-fold selectivity over other HMTases (SMYD3, SUV420H1, SUV420H2, etc.) and other non-epigenetic targets.
BAY-598 inhibits the methylation of p53K370 in cells with IC50 <1 uM, has properties that are compatible with in vivo experiments.
