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Chemical Structure : BCI-121
CAS No.: 432529-82-3
Catalog No.: PC-70108Not For Human Use, Lab Use Only.
BCI-121 (BCI121) is a substrate-competitive SMYD3 inhibitor that significantly inhibits SMYD3-substrate interaction and chromatin recruitment and is effective in reducing proliferation in various cancer cells types.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $398 | In stock | |
| 250 mg | Get quote |
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BCI-121 (BCI121) is a substrate-competitive SMYD3 inhibitor that significantly inhibits SMYD3-substrate interaction and chromatin recruitment and is effective in reducing proliferation in various cancer cells types.
BCI-121 impairs SMYD3-mediated H4 in vitro methylation, reduced proliferation of HT29 and HCT116 cells.
BCI-121 reproduces the effects of SMYD3-targeted RNAi.
| M.Wt | 340.22 | |
| Formula | C14H18BrN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(Aminocarbonyl)-N-(4-bromophenyl)-1-piperidineacetamide |
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1. Peserico A, et al. J Cell Physiol. 2015 Oct;230(10):2447-2460.
2. Huang L, et al. Am J Transl Res. 2017 Jan 15;9(1):1-14.
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