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Chemical Structure : CPI-1205
CAS No.: 1621862-70-1
Catalog No.: PC-60299Not For Human Use, Lab Use Only.
Lirametostat (CPI-1205) is a highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | $598 | In stock | |
| 100 mg | $898 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Lirametostat (CPI-1205) is a highly potent, selective EZH2 inhibitor with biochemical IC50 of 2 nM, cellular EC50 of 32 nM.
Lirametostat (CPI-1205) demonstrates modest selectivity over EZH1 (IC50=52 nM), and a clean selectivity profile against 30 other histone or DNA methyltransferases.
Lirametostat (CPI-1205) exhibits robust antitumor effects in a Karpas-422 xenograft model (at 160 mg/kg BID).
| M.Wt | 518.57 | |
| Formula | C27H33F3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
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1. Vaswani RG, et al. J Med Chem. 2016 Nov 10;59(21):9928-9941.
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