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Chemical Structure : MM-589
CAS No.: 2097887-21-1
Catalog No.: PC-70104Not For Human Use, Lab Use Only.
A highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.
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MM-589 is a highly potent, cell-permeable inhibitor of WDR5-MLL interaction with IC50 of 0.9 nM, Ki of <1 nM.
MM-589 inhibits the MLL H3K4 methyltransferase activity (IC50=12.7 nM), potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations, and shows >40-fold better than MM-401.
| M.Wt | 686.734 | |
| Formula | C30H45F3N8O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-((3R,6S,9S,12R)-6-ethyl-12-methyl-9-(3-(3-methylguanidino)propyl)-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl)isobutyramide 2,2,2-trifluoroacetate |
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1. Karatas H, et al. J Med Chem. 2017 Jun 22;60(12):4818-4839.
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