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Cat. No. Product Name Information
PC-73322

EZM0414

SETD2 inhibitor

EZM 0414 is a potent, selective and orally bioavailable inhibitor of histone methyltransferase SETD2 with biochemical IC50 of 18 nM, >10,000-fold selectivity over other HMTases.
PC-73122

MRK-740

PRDM9 inhibitor

MRK-740 (MRK740) is a first-in-class, potent, selective and cell-active PRDM9 inhibitor with IC50 of 80 nM.
PC-73067

BR-001

PRC2 EED inhibitor

BR-001 (BR001) is a potent, selective, allosteric inhibitor of EED subunit of PRC2 complex, disrupts EED-H3K27me3 interaction (IC50=4.5 nM).
PC-73054

PFI-5

SMYD2 inhibitor

PFI-5 a highly biochemically potent, selective, and cell-active SMYD2 chemical probe with IC50 of 8 nM.
PC-73027

SPIN1 inhibitor MS31

SPIN1 inhibitor

SPIN1 inhibitor MS31 (MS31) is a potent, selective, and cell-active inhibitor of methyllysine reader protein SPIN1 (spindlin 1) with IC50 of 77 nM.
PC-72992

SMYD3 inhibitor 29

SMYD3 inhibitor

SMYD3 inhibitor 29 is a highly potent, selective, covalent inhibitor of histone methyltransferase SMYD3 with IC50 of 1.7 nM.
PC-72793

SNDX5613

menin-MLL inhibitor

Revumenib (SNDX-5613) is a potent and selective inhibitor of menin-MLL binding with Ki of 0.149 nM.
PC-72792

VTP50469

menin-MLL inhibitor

VTP50469 (VTP 50469) is potent, selective, orally active inhibitor of Menin-MLL interaction with Ki of 104 pM.
PC-72717

NAH-C3-GPKK

NTMT1/KMT9 inhibitor

NAH-C3-GPKK is a potent, selective protein N-terminal methyltransferase 1 (NTMT1) bisubstrate inhibitor with Kiapp of 7 nM in endogenous proteomes.
PC-72640

SGC6870N

PRMT6 inhibitor

SGC6870N is the negative control of SGC-6870 (R-isomer), which is a potent, selective, cell-active PRMT6 inhibitor.
PC-72639

SGC6870

PRMT6 inhibitor

SGC6870 (SGC-6870 (R-isomer)) is a potent, selective, cell-active PRMT6 inhibitor with IC50 of 77 nM.
PC-72620

PF-06821497

EZH2 Y641N inhibitor

PF-06821497 (PF 06821497) is a potent, selective, orally bioavailable Enhancer of Zeste Homolog 2 (EZH2) inhibitor with Ki of <1 nM against Y641N mutant.

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