| Cat. No. |
Product Name |
Information |
| PC-26996 |
TNG917
EHMT1/2 inhibitor
|
TNG917 is a potent, selective, histone substrate-competitive, orally active dual inhibitor of EHMT1/2, shows high selectivity over other methyltransferases. |
| PC-26788 |
AZD3470
PRMT5 inhibitor
|
AZD3470 (AZD-3470) is a potent, seleective MTA-cooperative PRMT5 inhibitor, targets MTAP deficient advanced/metastatic cancer cells. |
| PC-26787 |
TNG456
PRMT5 inhibitor
|
TNG456 is a potent, highly selective, brain-penetrant MTA-cooperative PRMT5 inhibitor with Ki,app of <2 pM, exhibits viability growth inhibition with GI50 of 20 nM for HAP1 MTAP-null cells, 50-fold selective over HAP1 MTAP WT cells. |
| PC-26595 |
SCR-6920
PRMT5 inhibitor
|
SCR-6920 is a potent and selective, oral PRMT5 inhibitor with IC50 of 1.48 nM. |
| PC-26591 |
NSUN2 inhibitor AK
NSUN2 inhibitor
|
NSUN2 inhibitor AK (AK-968/36977265) is a small molecule inhibitor of RNA methyltransferase NSUN2, decreases m5C occupancy and GATM mRNA levels, shows anti-fibrotic efficacy. |
| PC-26589 |
UNC7242
PHF1/PHF19 inhibitor
|
UNC7242 is a small molecule antagonist of PRC2 components PHF1 and PHF19 with ITC Kd of 1.13 uM and 0.64 uM, displaces recombinant or endogenous PHF1 or 19 from nucleosomes. |
| PC-26542 |
EP102
METTL3 inhibitor
|
EP102 is a potent, selective METTL3 inhibitor with IC50 of 2 nM in SPA primary assay. |
| PC-26532 |
METTL16-IN-1
METTL16 inhibitor
|
METTL16-IN-1 is a specific small molecule METTL16 inhibitor with IC50 of 1.7 uM against the METTL16-RNA binding. |
| PC-26496 |
C191-0266
METTL3 inhibitor
|
C191-0266 is a small molecule inhibitor of METTL3 with KD of 7.28 uM and enzymatic IC50 of 7.84 uM. |
| PC-26384 |
METTL9i
METTL9 inhibitor
|
METTL9i is a first-in-class, highly potent, selective and cell-active methyltransferase METTL9 inhibitor with IC50 of 67 nM. |
| PC-26274 |
SGSS05NS
SETD8 inhibitor
|
SGSS05NS is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 0.54 uM, covalently modifies SETD8 at Cys311. |
| PC-26273 |
MS4138
SETD8 inhibitor
|
MS4138 is a potent, selective and covalent inhibitor of protein lysine methyltransferase (PKMT) SETD8 with IC50 of 1.4 uM, covalently modifies SETD8 at Cys311. |
