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Cat. No. Product Name Information
PC-49728

UNC0642

G9a/GLP inhibitor

UNC0642 (UNC 0642) is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor with IC50 of <2.5 nM.
PC-49724

JS1310

PRMT7 inhibitor

JS1310 (JS-1310) is a specific small-molecule PRMT7 inhibitor with IC50 of 5 uM (human PRMT7), displays no acitivity against type I PRMTs (PRMT1, 3, 4, 6, and 8, IC50 >100 uM) or the type II PRMT5 (IC50=50 uM).
PC-49699

SKLB-03220

EZH2 inhibitor

SKLB-03220 (SKLB03220) is a potent, selective EZH2 covalent inhibitor with IC50 of 1.72 nM (EZH2 WT).
PC-49683

CDIBA

METTL3-14 inhibitor

CDIBA is an allosteric inhibitors of m6A-RNA methyltransferase, METTL3 -14 complex with IC50 of 17.3 uM, also reported as a cytosolic phospholipase A2 (cPLA2) inhibitor.
PC-49679

METTL3 inhibitor UZH2

METTL3 inhibitor

METTL3 inhibitor UZH2 is a potent, selective and cell-permeable RNA methyltransferase METTL3 inhibitor with IC50 of 5 nM in TR-FRET assays.
PC-49674

IHMT-337

EZH2 inhibitor

IHMT-337 (IHMT337) is a potent, highly selective and irreversible EZH2 inhibitor, specifically inhibits the methylation at H3K27.
PC-49612

RK-701

G9a/GLP inhibitor

RK-701 (RK701) is a potent, highly selective and reversible histone lysine methyltransferases G9a and G9a-like protein (GLP) inhibitor with IC50 of 23-27 nM and 53 nM, respectively.
PC-49598

WDR5 inhibitor 10

WDR5 inhibitor

WDR5 inhibitor 10 is a highly potent, selective and orally active inhibitor of WD repeat domain 5 (WDR5) with TR-FRET Ki value of <0.02 nM, shows potent antiproliferative activity with GI50 of 9.7 nM in MV4:11 cells.
PC-49559

PRT382

PRMT5 inhibitor

PRT382 (PRT-382) is a potent, selective and SAM-competitive PRMT5 inhibitor with IC50 of 2.8 nM in filtration binding assays with recombinant human PRMT5/MEP50 and histone H2A as the protein substrate.
PC-49558

CWI1-2

IGF2BP2 inhibitor

CWI1-2 is a small molecule inhibitor of m6A reader IGF2BP2, shows promising anti-leukemia effects in vitro and in vivo.
PC-49506

WDR5 WIN site inhibitor 16

WDR5 inhibitor

WDR5 WIN site inhibitor 16 is a potent, selective inhibitor of WD repeat domain 5 (WDR5) WIN site with TR-FRET Kd of <0.02 nM, exhibits histone methyltransferase inhibition with IC50 of 2.2 nM.
PC-49393

EPIC-0412

HOTAIR-EZH2 inhibitor

EPIC-0412 is a small-molecule inhibitor that enhances the chemotherapeutic effect of temozolomide (TMZ) by acting on the p21-E2F1 DNA damage repair axis and ATF3-p-p65-MGMT axis.

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