Catalog No.: PC-21568Not For Human Use, Lab Use Only.
BN-104 (Zefamenib, BNM-1192) is a potent, highly selective small molecule menin-MLL inhibitor, BNM-1192 is very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant (MV-4-11 (AF4 fusion), IC50=3.5 nM).
BN-104 (Zefamenib, BNM-1192) is a potent, highly selective small molecule menin-MLL inhibitor, BNM-1192 is very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant (MV-4-11 (AF4 fusion), IC50=3.5 nM).
BN104 (BNM-1192) has 1000-fold selectivity over control cell line, HL-60 (MLL wild type).
BN104 (BNM-1192) showed optimized drug-like properties and excellent efficacy in MV4-11 xenograft mouse model.
