BN104 | menin-MLL inhibitor | Probechem Biochemicals

Chemical Structure : BN104

BN104 (BN 104, BNM-1192)

Catalog No.: PC-21568Not For Human Use, Lab Use Only.

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Biological Activity

BN104 (BNM-1192) is a potent, highly selective small molecule menin-MLL inhibitor, BNM-1192 is very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant (MV-4-11 (AF4 fusion), IC50=3.5 nM).
BN104 (BNM-1192) has 1000-fold selectivity over control cell line, HL-60 (MLL wild type)。
BN104 (BNM-1192) showed optimized drug-like properties and excellent efficacy in MV4-11 xenograft mouse model.

Physicochemical Properties

M.Wt	569.69
Formula	C32H36FN7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [2-[6-[2-(4-cyclopropyl-5-pyrimidinyl)-4-fluorophenoxy]-1,2,4-triazin-5-yl]-2,7-diazaspiro[3.5]non-7-yl][(1S,3aR,6aS)-octahydrocyclopenta[c]pyrrol-1-yl]-

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BN104 (BN 104, BNM-1192)

Biological Activity

Physicochemical Properties

References

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