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Chemical Structure : BN104
Catalog No.: PC-21568Not For Human Use, Lab Use Only.
BN104 (BNM-1192) is a potent, highly selective small molecule menin-MLL inhibitor, BNM-1192 is very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant (MV-4-11 (AF4 fusion), IC50=3.5 nM).
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BN104 (BNM-1192) is a potent, highly selective small molecule menin-MLL inhibitor, BNM-1192 is very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant (MV-4-11 (AF4 fusion), IC50=3.5 nM).
BN104 (BNM-1192) has 1000-fold selectivity over control cell line, HL-60 (MLL wild type)。
BN104 (BNM-1192) showed optimized drug-like properties and excellent efficacy in MV4-11 xenograft mouse model.
| M.Wt | 569.69 | |
| Formula | C32H36FN7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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