| Cat. No. |
Product Name |
Information |
| PC-23238 |
YD1342
PRMT4 inhibitor
|
YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM). |
| PC-23237 |
YD1130
PRMT4 inhibitor
|
YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs. |
| PC-23204 |
SETD8 inhibitor C23
SETD8 inhibitor
|
SETD8 inhibitor C23 (RL5a) is a novel chemical inhibitor of SETD8, inhibits H4K20 methylation, inhibits IR-induced 53BP1 foci. |
| PC-23137 |
UNC10013
SETDB1 modulator
|
UNC10013 is a potent, selective and cell-active covalent ligand/negative allosteric modulator of triple Tudor domain (3TD) of SETDB1 with TR-FRET IC50 of 57 nM, targets the Cys385 of SETDB1. |
| PC-23098 |
Igermetostat
EZH2 inhibitor
|
Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2. |
| PC-23080 |
DCPT1061
Type I PRMTs inhibitor
|
DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. |
| PC-23078 |
MS117
PRMT6 inhibitor
|
MS117 is a potent, selective and cell-active covalent PRMT6 inhibitor with Ki of 16 nM and IC50 of 18 nM. |
| PC-23070 |
ZYZ384
SMYD3 inhibitor
|
ZYZ384 (ZYZ-384) is a small molecule inhibitor of histone lysine methyltransferase SMYD3 with KD value of 78 uM, reduces cell proliferation against human hepatoma HepG2 cells with IC50 of 5.23 uM. |
| PC-23026 |
NSD2 inhibitor 42
NSD2 inhibitor
|
NSD2 inhibitor 42 (W4275) is a potent, selective inhibitor of histone lysine methyltransferase NSD2 with IC50 of 17 nM. |
| PC-22999 |
DOT1L R231Q inhibitor 37
DOT1L R231Q inhibitor
|
DOT1L R231Q inhibitor 37 is a first-in-class DOT1L R231Q inhibitor, inhibits proliferation of H460 cells expressing DOT1LR231Q with IC50 of 6.18 uM. |
| PC-22924 |
EML425
CBP/p300 inhibitor
|
EML425 is a potent, selective, cell-permeable and reversible inhibitor of KAT3 histone acetyltransferases (CBP and p300) with IC50 of 1.1 and 2.9 uM respectively. |
| PC-22923 |
MS3745
G9a-like protein inhibitor
|
MS3745 is a potent and selective inhibitor of protein lysine methyltransferase G9a-like protein (GLP) with IC50 of 4 nM, 65-fold selective over G9a. |
