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Cat. No. Product Name Information
PC-72045

F5446

SUV39H1 inhibitor

F5446 (F 5446) is a specific small molecule inhibitor of H3K9me3-specific histone methyltransferase SUV39H1 with EC50 of 0.496 uM in an in vitro enzymatic activity assay.
PC-72008

TC-5115

MLL1 SET domain

TC-5115 (TC5115 ) is a potent, selective inhibitor of MLL1 SET domain with IC50 of 15 nM, 48 times more potent than the pan-methyltransferase inhibitor SAH.
PC-38300

MS1943

EZH2 degrader

MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM.
PC-38218

BAY-155

menin-MLL inhibitor

BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503.
PC-38209

DC541

NTMT1 inhibitor

DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM.
PC-38151

SHIN1

SHMT1/2 inhibitor

SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM.
PC-38150

SHIN2

SHMT1/2 inhibitor

SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1.
PC-38010

MU1656

DOT1L inhibitor

MU1656 (MU 1656 ) is a potent, highly selective inhibitor of histone methyltransferase DOT1L with IC50 of 2 nM.
PC-36120

WDR5 WIN site inhibitor C3

WDR5 inhibitor

WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM.
PC-36119

WDR5 WIN site inhibitor C6

WDR5 inhibitor

WDR5 inhibitor C6 (WDR5-IN-4) is a highly potent WDR5 WIN site inhibitor with Kd of 0.1 nM.
PC-36041

NPD13668

EZH2 inhibitor

NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.
PC-35850

LEM-14-1189

NSD2 inhibitor

LEM-14-1189 is a LEM-14 derivative that differentially inhibits the NSDs with in vitro IC50 of 418 μM (NSD1), IC50 of 111 μM (NSD2) and IC50 of 60 μM (NSD3).

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