| Cat. No. |
Product Name |
Information |
| PC-62527 |
PF-06726304
EZH2 inhibitor
|
PF-06726304 is a novel potent enhancer of zeste homolog 2 (EZH2) inhibitor with IC50 of <5 nM, Ki of 0.7/3.0 nM (Wt/Y641N). |
| PC-62526 |
EBI-2511
EZH2 inhibitor
|
EBI-2511 is a highly potent and orally active EZH2 inhibitor with IC50 of 4 nM against mutant EZH2 A677G. |
| PC-62486 |
M-525
Menin-MLL inhibitor
|
M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays. |
| PC-62485 |
MI-2-2
Menin-MLL inhibitor
|
MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM). |
| PC-62409 |
MMSET-IN-1
NSD2 inhibitor
|
MMSET-IN-1 (NSD2 inhibitor 1) is a potent, selective epigenetic oncogene MMSET (aka NSD2 or WHSC1) inhibitor with Ki/IC50 of 1.6/3.3 uM. |
| PC-62385 |
UNC-2170 maleate
53BP1 inhibitor
|
UNC-2170 maleate is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain. |
| PC-62384 |
UNC-2170
53BP1 inhibitor
|
UNC-2170 is a small molecule ligand for the methyl-lysine binding protein 53BP1 (p53-binding protein 1) with Kd of 22 uM against the 53BP1 tandem tudor domain. |
| PC-62309 |
A-395
PRC2 EED inhibitor
|
A-395 (A395) is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM. |
| PC-62142 |
ML399
Menin-MLL inhibitor
|
ML399 (VU0516340) is a potent and cell penetrant menin-MLL inhibitor with IC50 of 90 nM. |
| PC-61791 |
PR5-LL-CM01
PRMT5 inhibitor
|
PR5-LL-CM01 is a novel selective, small-molecule inhibitor of PRMT5 methyltransferase with IC50 of 7.5 uM. |
| PC-61403 |
Valemetostat
EZH1/EZH2 inhibitor
|
Valemetostat (DS-3201, DS3201) is a potent, selective, dual EZH1/EZH2 inhibitor with IC50 <10 nM. |
| PC-61209 |
EPZ 025654
CARM1 inhibitor
|
EPZ025654 (GSK 35336023) is a potent, selective arginine methyltransferase CARM1 inhibitor with IC50 of 3 nM. |
