| Cat. No. |
Product Name |
Information |
| PC-72291 |
PRC2 EED-IN-1
PRC2 EED inhibitor
|
PRC2 EED-IN-1 is a potent, selective, allosteric, orally bioavailable inhibitor of the EED subunit of histone methyltransferase PRC2 with IC50 of 44 nM (H3K27me3 inhibition). |
| PC-72290 |
OR-S0
EZH2 inhibitor
|
OR-S0 is a potent, selective EZH2 inhibitor with IC50 of 11 nM, weakly inhibitor EZH1 (IC50=91 nM). |
| PC-72288 |
ZLD1039
EZH2 inhibitor
|
ZLD1039 (ZLD 1039) is a potent, highly selective, and orally bioavailable small molecule inhibitor of EZH2 with IC50 of 5.6, 15, 4.0 nM against EZH2 WT, Y641F, and A677G mutations respectively. |
| PC-72287 |
SKLB-03176
EZH2 inhibitor
|
SKLB-03176 (SKLB03176) is a potent, selective, covalent EZH2 inhibitor with IC50 of 47 nM, covalently binds to the SAM pocket of EZH2. |
| PC-72046 |
MI-3454
menin-MLL1 inhibitor
|
MI-3454 (MI 3454) is a highly potent, orally bioavailable inhibitor of the menin-MLL1 interaction with IC50 of 0.51 nM, 60-fold improvement over MI-503. |
| PC-72045 |
F5446
SUV39H1 inhibitor
|
F5446 (F 5446) is a specific small molecule inhibitor of H3K9me3-specific histone methyltransferase SUV39H1 with EC50 of 0.496 uM in an in vitro enzymatic activity assay. |
| PC-72008 |
TC-5115
MLL1 SET domain
|
TC-5115 (TC5115 ) is a potent, selective inhibitor of MLL1 SET domain with IC50 of 15 nM, 48 times more potent than the pan-methyltransferase inhibitor SAH. |
| PC-38300 |
MS1943
EZH2 degrader
|
MS1943 (MS-1943) is a first-in-class, orally bioavailable EZH2 selective degrader that effectively reduces EZH2 levels in cells, inhibits EZH2 methyltransferase activity with IC50 of 120 nM. |
| PC-38218 |
BAY-155
menin-MLL inhibitor
|
BAY-155 (BAY155) is a novel, potent and selective menin-MLL inhibitor with binding IC50 of 8 nM, 10-fold better compared to that of MI-503. |
| PC-38209 |
DC541
NTMT1 inhibitor
|
DC541 (DC 541) is a potent, selective peptidomimetic inhibitor of Protein N-terminal methyltransferase NTMT1 with IC50 of 0.34 uM. |
| PC-38151 |
SHIN1
SHMT1/2 inhibitor
|
SHIN1 (RZ-2994, RZ 2994) is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with biochemical IC50 of 5/13 nM. |
| PC-38150 |
SHIN2
SHMT1/2 inhibitor
|
SHIN2 is a folate-competitive, cell-permeable inhibitor of human SHMT1/2 with improved pharmacokinetic properties over SHIN1. |
