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AH237

Chemical Structure : AH237

CAS No.:

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AH237 (AH-237)

Catalog No.: PC-72468Not For Human Use, Lab Use Only.

AH237 (AH-237) is a potent and selective inhibitor for PRMT4 and PRMT5 with IC50 of 2.8 and 0.42 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AH237 (AH-237) is a potent and selective inhibitor for PRMT4 and PRMT5 with IC50 of 2.8 and 0.42 nM, respectively.
    AH237 (AH-237) displayed over 50-fold selectivity against a panel of 41 MTases such as PRMTs, PKMTs, NTMT1/2, and DNA methyltransferases (DNMTs), Its potency was also confirmed for PRMT1 (IC50 = 5.9 uM) and PRMT7 (IC50 = 831 nM).

    Physicochemical Properties

    M.Wt 695.805
    Formula C26H45N15O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-amino-N-((S)-1-((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)-11-carbamoyl-7-imino-13-oxo-2-thia-6,8,12-triazatetradecan-14-yl)-5-guanidinopentanamide

    References

    1. Ayad A Al-Hamashi, et al. Acta Pharm Sin B. 2021 Sep;11(9):2709-2718.

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