BRD0639 | PRMT5 inhibitor | Probechem Biochemicals

Chemical Structure : BRD0639

CAS No.: 2760881-74-9

BRD0639 (BRD-0639)

Catalog No.: PC-72495Not For Human Use, Lab Use Only.

BRD0639 (BRD-0639) is a first-in-class, specific inhibitor of interaction between PRMT5 and its substrate adaptor protein (PRMT5 binding motif) with IC50 of 13.8 uM.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$188	In stock
25 mg	$328	In stock
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

BRD0639 (BRD-0639) is a first-in-class, specific inhibitor of interaction between PRMT5 and its substrate adaptor protein (PRMT5 binding motif) with IC50 of 13.8 uM.
BRD0639 engages the target in cells, disrupts PRMT5-RIOK1 complexes, and reduces substrate methylation.

Physicochemical Properties

M.Wt	475.948
Formula	C21H22ClN5O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-(N-(2-(pyridin-2-yl)ethyl)sulfamoyl)phenyl)propanamide

References

1. David C McKinney, et al. J Med Chem. 2021 Aug 12;64(15):11148-11168.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com

BRD0639 (BRD-0639)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.