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Chemical Structure : BRD0639
CAS No.: 2760881-74-9
Catalog No.: PC-72495Not For Human Use, Lab Use Only.
BRD0639 (BRD-0639) is a first-in-class, specific inhibitor of interaction between PRMT5 and its substrate adaptor protein (PRMT5 binding motif) with IC50 of 13.8 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BRD0639 (BRD-0639) is a first-in-class, specific inhibitor of interaction between PRMT5 and its substrate adaptor protein (PRMT5 binding motif) with IC50 of 13.8 uM.
BRD0639 engages the target in cells, disrupts PRMT5-RIOK1 complexes, and reduces substrate methylation.
| M.Wt | 475.948 | |
| Formula | C21H22ClN5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-(4-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-(N-(2-(pyridin-2-yl)ethyl)sulfamoyl)phenyl)propanamide |
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1. David C McKinney, et al. J Med Chem. 2021 Aug 12;64(15):11148-11168.
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