You are here:Home-Chemical Inhibitors & Agonists-Epigenetics-Histone Methyltransferase (HMTase)

Request The Product List ofHistone Methyltransferase (HMTase) Histone Methyltransferase (HMTase)

Cat. No. Product Name Information
PC-35104

MI-1481

Menin-MLL1 inhibitor

MI-1481 (MI1481) is a highly potent inhibitor of the menin-MLL1 interaction with IC50 of 3.6 nM, 10-fold increase in inhibitory activity over MI-463 and MI-503.
PC-35043

DS-437

PRMT5/7 inhibitor

DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases.
PC-35042

CARM1 inhibitor 9

CARM1 inhibitor

CARM1 inhibitor 9 is a potent, selective inhibitor of arginine methyltransferase 1 (CARM1, PRMT4) with IC50 of 94 nM.
PC-35041

TBBD

CARM1 inhibitor

TBBD (Ellagic acid) is a specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17).
PC-63547

TP-064N

TP-064 control

TP-064N is a negative control chemical of TP-064, which is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM..
PC-63546

TP-064

PRMT4 inhibitor

TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs.
PC-63538

T1551

PRMT5 inhibitor

T1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM, exhibits anti-proliferation on A549 cell with IC50 of 11.2 uM.
PC-63461

LLY-283

PRMT5 inhibitor

LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.
PC-63250

BAY-6035

BAY-6035 is a potent, peptide-competitive inhibitor of histone methyltransferase SMYD3, inhibits in vitro methylation of MEKK2 peptide with IC50 of 88 nM, >100-fold selectivity over other HMTases.
PC-43301

EPZ020411 hydrochloride

PRMT6 inhibitor

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).
PC-43300

EPZ020411

PRMT6 inhibitor

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).
PC-43259

GSK503

EZH2 inhibitor

GSK503 is a potent, specific EZH2 methyltransferase inhibitor that inhibits the methyltransferase activity of WT and mutant EZH2 with similar potency (Ki app=3-27 nM).

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com