| Cat. No. |
Product Name |
Information |
| PC-35591 |
MAK683
PRC2 EED inhibitor
|
MAK683 (MAK-683) is a potent and selective EED inhibitor with biochemical IC50 of 9 nM, and allosteric inhibitor of polycomb repressive complex 2 (PRC2), selectively binds to the domain of EED that interacts with H3K27me3). |
| PC-35520 |
PF-06855800
PRMT5 inhibitor
|
PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM. |
| PC-35432 |
Gambogenic acid
EZH2 inhibitor
|
Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge, shows potent antitumor activity and can effectively inhibit the survival and proliferation of cancer cells. |
| PC-35431 |
GNA002
EZH2 inhibitor
|
GNA002 (GNA-002) is a gambogenic acid (GNA) derivative that specifically and covalently binds to Cys668 within the EZH2-SET domain, trigges EZH2 degradation (IC50=1.1 uM) through COOH terminus of Hsp70-interacting protein (CHIP)-mediated ubiquitination. |
| PC-35247 |
WDR5-MLL1 inhibitor
WDR5-MLL1 inhibitor
|
WDR5-MLL1 inhibitor is a novel potent inhibitor of WDR5-MLL1 interaction, binds to WDR5 with Kd of 1 nM. |
| PC-35104 |
MI-1481
Menin-MLL1 inhibitor
|
MI-1481 (MI1481) is a highly potent inhibitor of the menin-MLL1 interaction with IC50 of 3.6 nM, 10-fold increase in inhibitory activity over MI-463 and MI-503. |
| PC-35043 |
DS-437
PRMT5/7 inhibitor
|
DS-437 is a potent, selective, dual inhibitor of PRMT5 and PRMT7 with IC50 of 6.0 uM for both, DS-437 is inactive against 29 other human protein-, DNA-, and RNA-methyltransferases. |
| PC-35042 |
CARM1 inhibitor 9
CARM1 inhibitor
|
CARM1 inhibitor 9 is a potent, selective inhibitor of arginine methyltransferase 1 (CARM1, PRMT4) with IC50 of 94 nM. |
| PC-35041 |
TBBD
CARM1 inhibitor
|
TBBD (Ellagic acid) is a specific inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4) that selectively inhibits methylation at arginine 17 of histone H3 (H3R17). |
| PC-63547 |
TP-064N
TP-064 control
|
TP-064N is a negative control chemical of TP-064, which is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM.. |
| PC-63546 |
TP-064
PRMT4 inhibitor
|
TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs. |
| PC-63538 |
T1551
PRMT5 inhibitor
|
T1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM, exhibits anti-proliferation on A549 cell with IC50 of 11.2 uM. |
