| Cat. No. |
Product Name |
Information |
| PC-45489 |
PFI-2 hydrochloride
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) hydrochloride is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-45488 |
PFI-2
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-23621 |
AS-254
ASH1L inhibitor
|
AS-254 is a highly potent and selective histone lysine methyltransferase ASH1L (absent, small, or homeotic-like 1) inhibitor with IC50 of 94 nM in FP assays, binds to the catalytic SET domain of ASH1L with ITC Kd of 179 nM. |
| PC-23618 |
AS-254s
ASH1L inhibitor
|
AS-254s is a highly potent and selective histone lysine methyltransferase ASH1L (absent, small, or homeotic-like 1) inhibitor with IC50 of 94 nM in FP assays, binds to the catalytic SET domain of ASH1L with ITC Kd of 179 nM. |
| PC-23492 |
ASH1L inhibitor AS-99 TFA
ASH1L inhibitor
|
ASH1L inhibitor AS-99 TFA (AS99) is a first-in-class, potent, selective inhibitor of ASH1L histone methyltransferase with IC50 of 0.79 uM. |
| PC-23491 |
ASH1L inhibitor AS-85 hydrochloride
ASH1L inhibitor
|
ASH1L inhibitor AS-85 hydrochloride (AS85) is a first-in-class, potent, selective inhibitor of ASH1L histone methyltransferase with IC50 of 0.6 uM. |
| PC-23490 |
ASH1L inhibitor AS-85
ASH1L inhibitor
|
ASH1L inhibitor AS-85 (AS85) is a first-in-class, potent, selective inhibitor of ASH1L histone methyltransferase with IC50 of 0.6 uM. |
| PC-23344 |
BR0063
PRC2 inhibitor
|
BR0063 is a potent, selective EED-directed allosteric inhibitor of polycomb repressive complex 2 (PRC2), efficiently blocks the interaction of the EED subunit with H3K27me3 (EC50=5.9 nM), which led to the marked inhibition of cellular PRC2 activity. |
| PC-23238 |
YD1342
PRMT4 inhibitor
|
YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM). |
| PC-23237 |
YD1130
PRMT4 inhibitor
|
YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs. |
| PC-23204 |
SETD8 inhibitor C23
SETD8 inhibitor
|
SETD8 inhibitor C23 is a novel chemical inhibitor of SETD8, inhibits H4K20 methylation, inhibits IR-induced 53BP1 foci. |
| PC-23137 |
UNC10013
SETDB1 modulator
|
UNC10013 is a potent, selective and cell-active covalent ligand/negative allosteric modulator of triple Tudor domain (3TD) of SETDB1 with TR-FRET IC50 of 57 nM, targets the Cys385 of SETDB1. |
