| Cat. No. |
Product Name |
Information |
| PC-45488 |
PFI-2
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-23344 |
BR0063
PRC2 inhibitor
|
BR0063 is a potent, selective EED-directed allosteric inhibitor of polycomb repressive complex 2 (PRC2), efficiently blocks the interaction of the EED subunit with H3K27me3 (EC50=5.9 nM), which led to the marked inhibition of cellular PRC2 activity. |
| PC-23238 |
YD1342
PRMT4 inhibitor
|
YD1342 is the in-vivo active prodrug of YD1130, a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM). |
| PC-23237 |
YD1130
PRMT4 inhibitor
|
YD1130 is a potent, selective PRMT4 inhibitor with IC50 of <1 nM, 1000-fold selectivity for PRMT4 (IC50 < 0.5 nM) over a panel of 38 methyltransferases, including the other PRMTs. |
| PC-23204 |
SETD8 inhibitor C23
SETD8 inhibitor
|
SETD8 inhibitor C23 is a novel chemical inhibitor of SETD8, inhibits H4K20 methylation, inhibits IR-induced 53BP1 foci. |
| PC-23137 |
UNC10013
SETDB1 modulator
|
UNC10013 is a potent, selective and cell-active covalent ligand/negative allosteric modulator of triple Tudor domain (3TD) of SETDB1 with TR-FRET IC50 of 57 nM, targets the Cys385 of SETDB1. |
| PC-23098 |
Igermetostat
EZH2 inhibitor
|
Igermetostat (XNW5004) is a potent, selective EZH2 inhibitor which potently inhibits both wild type and mutant EZH2. |
| PC-23080 |
DCPT1061
Type I PRMTs inhibitor
|
DCPT1061 is a selective inhibitor of type I PRMT subfamily members, potently inhibits PRMT1, PRMT6, and PRMT8, with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. |
| PC-23079 |
MS167
PRMT6 inhibitor
|
MS167 is a potent, selective and cell-active reversible PRMT6 inhibitor with IC50 of 28 nM. |
| PC-23078 |
MS117
PRMT6 inhibitor
|
MS117 is a potent, selective and cell-active covalent PRMT6 inhibitor with Ki of 16 nM and IC50 of 18 nM. |
| PC-23070 |
ZYZ384
SMYD3 inhibitor
|
ZYZ384 is a small molecule inhibitor of histone lysine methyltransferase SMYD3 with KD value of 78 uM, reduces cell proliferation against human hepatoma HepG2 cells with IC50 of 5.23 uM. |
| PC-22999 |
DOT1L R231Q inhibitor 37
DOT1L R231Q inhibitor
|
DOT1L R231Q inhibitor 37 is a first-in-class DOT1L R231Q inhibitor, inhibits proliferation of H460 cells expressing DOT1LR231Q with IC50 of 6.18 uM. |
