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GSK3326595

Chemical Structure : GSK3326595

CAS No.: 1616392-22-3

GSK3326595 (Pemrametostat, GSK-3326595, EPZ015938)

Catalog No.: PC-42405Not For Human Use, Lab Use Only.

Pemrametostat (GSK3326595, EPZ015938) is a potent, selective, reversible and orally active PRMT5 inhibitor with IC50 of 22 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pemrametostat (GSK3326595, EPZ015938) is a potent, selective, reversible and orally active PRMT5 inhibitor with IC50 of 22 nM.

Physicochemical Properties

M.Wt 452.54928
Formula C24H32N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

4-Pyrimidinecarboxamide, 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-

References

1. Drew Rasco, et al. Abstract CT038, AACR. DOI: 10.1158/1538-7445.

2. Patent WO 2016022605 A1, Formula A.

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