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Chemical Structure : EPZ031686
CAS No.: 2095161-11-6
Catalog No.: PC-45608Not For Human Use, Lab Use Only.
EPZ031686 (EPZ 031686) is a potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM, Cell IC50= 36 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | $788 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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EPZ031686 (EPZ 031686) is a potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM, Cell IC50= 36 nM).
EPZ031686 displays <30% inhibition against 16 histone methyltransferase targets at 10 uM.
EPZ031686 shows good oral bioavailability and more favorable ADME profile than EPZ030456; orally active.
| M.Wt | 591.0858 | |
| Formula | C26H34ClF3N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 5.9 mg/mL |
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| Chemical Name/SMILES |
1H-Indole-5-carboxamide, 6-chloro-2,3-dihydro-2-oxo-N-[(3-endo)-8-[[[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl]sulfonyl]-8-azabicyclo[3.2.1]oct-3-yl]- |
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1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.
2. Rajajeyabalachandran G, et al. Expert Opin Ther Targets. 2017 Feb;21(2):145-157.
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